Department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, USA.
Department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, USA; Comparative Medicine Institute, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, USA; The WM Keck Behavioral Center, North Carolina State University, Raleigh, NC, USA; Program in Genetics, North Carolina State University, Raleigh, NC, USA.
Neurosci Lett. 2022 Jan 18;768:136379. doi: 10.1016/j.neulet.2021.136379. Epub 2021 Nov 30.
The transient receptor potential (TRP) channel superfamily responds to various physical, chemical, and environmental stimuli including the detection of sensations both harmful and non-harmful. Among these sensations is pruritus, or itch. There are at least 27 different TRP channels and about six of them are involved in pruriception. The function of these six receptors is primarily seen in the skin and the dorsal root ganglia. Identification and biological insights provided by these receptors in pruriception is important for human health as mutations and activations of many of these channels cause discomfort and disease. This review will focus on involvement of TRP channels in pruriception that may render these channels as the targets of many antagonistic topical medications, which may help patients' better cope with the pruritus that results from various cutaneous and systemic diseases.
瞬时受体电位 (TRP) 通道超家族对各种物理、化学和环境刺激作出反应，包括对有害和无害感觉的检测。其中一种感觉是瘙痒。至少有 27 种不同的 TRP 通道，其中约有 6 种参与痒觉传递。这 6 种受体的功能主要存在于皮肤和背根神经节中。这些受体在痒觉传递中的识别和生物学见解对人类健康很重要，因为许多这些通道的突变和激活会导致不适和疾病。本综述将重点关注 TRP 通道在痒觉传递中的作用，这些通道可能成为许多拮抗局部药物的靶点，这可能有助于患者更好地应对各种皮肤和系统性疾病引起的瘙痒。
