Busuttil A, O'Conor G T, Foster M E, Gurtsevitch V, Morten J E, Steel C M
J Pathol. 1986 Apr;148(4):293-300. doi: 10.1002/path.1711480405.
Tumours were raised in both congenitally athymic ('nude') Swiss mice and in neonatally thymectomized, Ara-C-protected, whole-body irradiated CBA mice by subcutaneous inoculation of cells from a variety of cultured human lines. In both types of animal, tumours tended to grow massively at the site of inoculation, with some infiltration of adjacent tissues but only rarely with evidence of metastatic spread. Tumours derived from Burkitt's lymphoma (BL) lines or from EB virus-transformed lymphoblastoid cell lines (LCL) were all classified as high grade malignant lymphomas with a limited range of appearances on conventional histological examination. In the material studied there were no consistent features distinguishing BL-derived from LCL-derived tumours. Cell lines originating from other haematopoietic malignancies tended to produce tumours interpreted as immunoblastic lymphomas though there were distinctive characteristics in some cases, such as highly convoluted or pleomorphic nuclei in the cells of some tumours derived from T-cell leukaemia lines and plasmacytoid differentiation in tumours originating from myeloma lines. Malignant cell lines of epithelial origin gave rise to tumours with the histological appearances of anaplastic carcinomas readily distinguishable from the high grade lymphomas produced by haematopoietic cells.
通过皮下接种来自多种培养的人类细胞系的细胞，在先天性无胸腺（“裸”）瑞士小鼠和新生期胸腺切除、阿糖胞苷保护、全身照射的CBA小鼠中诱发肿瘤。在这两种类型的动物中，肿瘤往往在接种部位大量生长，有一些邻近组织浸润，但很少有转移扩散的迹象。源自伯基特淋巴瘤（BL）细胞系或EB病毒转化的淋巴母细胞系（LCL）的肿瘤在传统组织学检查中均被归类为高级别恶性淋巴瘤，外观范围有限。在所研究的材料中，没有一致的特征来区分源自BL的肿瘤和源自LCL的肿瘤。源自其他造血系统恶性肿瘤的细胞系倾向于产生被解释为免疫母细胞淋巴瘤的肿瘤，尽管在某些情况下有独特的特征，例如一些源自T细胞白血病细胞系的肿瘤细胞中高度卷曲或多形性的细胞核，以及源自骨髓瘤细胞系的肿瘤中的浆细胞样分化。上皮起源的恶性细胞系产生的肿瘤具有间变性癌的组织学外观，很容易与造血细胞产生的高级别淋巴瘤区分开来。
