Watson R M, Braunstein B L, Watson A J, Hochberg M C, Provost T T
J Rheumatol. 1986 Feb;13(1):90-4.
Retrospective obstetric histories were obtained in 50 anti-Ro(SSA) antibody positive women (aged 15-50 years) and 47 anti-nRNP antibody positive women of similar age range. Twenty (40%) anti-Ro(SSA) positive women and 33 (70%) anti-nRNP positive women fulfilled the revised ARA criteria for systemic lupus erythematosus (SLE). Thirty-four anti-Ro(SSA) positive women had a total of 84 pregnancies with a fetal loss of 28%; 29 anti-nRNP positive women had a total of 63 pregnancies with a fetal loss of 19%. Although the overall frequency of fetal wastage between the 2 groups was not significantly different, analysis of the subgroup of SLE patients demonstrated a significantly greater fetal wastage in black anti-Ro(SSA) positive women (15 of 21, 71%) compared with black anti-nRNP positive women (5 of 28, 18% p less than .001). No significant difference in fetal wastage was noted between either the white SLE or the non-SLE women in either antibody group. These data suggest that black SLE patients with anti-Ro(SSA) antibody may be at increased risk of fetal wastage.
对50名抗Ro(SSA)抗体阳性女性（年龄在15至50岁之间）和47名年龄范围相似的抗nRNP抗体阳性女性进行了回顾性产科病史调查。20名（40%）抗Ro(SSA)阳性女性和33名（70%）抗nRNP阳性女性符合修订后的美国风湿病学会（ARA）系统性红斑狼疮（SLE）标准。34名抗Ro(SSA)阳性女性共有84次妊娠，胎儿丢失率为28%；29名抗nRNP阳性女性共有63次妊娠，胎儿丢失率为19%。虽然两组之间胎儿丢失的总体频率没有显著差异，但对SLE患者亚组的分析显示，黑人抗Ro(SSA)阳性女性（21例中有15例，71%）的胎儿丢失率显著高于黑人抗nRNP阳性女性（28例中有5例，18%，p<0.001）。在任何一个抗体组中，白人SLE女性或非SLE女性之间的胎儿丢失率均无显著差异。这些数据表明，患有抗Ro(SSA)抗体的黑人SLE患者胎儿丢失风险可能增加。
