十年全科医疗中的不良反应，计算机分析。
Adverse reactions in ten years' general practice, computer analysed.
作者信息
Johnson R A
出版信息
J R Soc Med. 1986 Mar;79(3):145-8. doi: 10.1177/014107688607900306.
A total of 167 264 symptoms were recorded in numerical shorthand during a ten years period in a general practice. Computer analysis yielded 1535 adverse reactions with the drug prescribed. Especially prominent were reactions from three antibiotics (13% of all reported reactions), most of which were alimentary symptoms. Ampicillin also induced rashes reported at a rate of 5.2 per thousand prescriptions. Reactions to an oral contraceptive (Minovlar) were the most frequent to a single named drug, being 25.9% of prescriptions for that drug. A worldwide total of around one trillion symptoms seems likely before AD 2000. Computers could be used to detect the unpredictable side effects, as with practolol. Various 'costs' involved are noted, together with wider questions.
在一家普通诊所的十年期间，共以数字速记法记录了167264种症状。计算机分析得出所开药物有1535例不良反应。特别突出的是三种抗生素引起的反应（占所有报告反应的13%），其中大多数是消化道症状。氨苄青霉素引起皮疹的报告发生率为每千张处方5.2例。对一种口服避孕药（米诺弗拉尔）的反应是单一指定药物中最常见的，占该药物处方的25.9%。到公元2000年之前，全球范围内症状总数似乎可能达到约一万亿。计算机可用于检测不可预测的副作用，就像检测心得宁那样。文中指出了所涉及的各种“成本”以及更广泛的问题。
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