Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Biochemistry, Cellular and Molecular Biology Graduate Program, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Neuron. 2022 Feb 2;110(3):486-501.e7. doi: 10.1016/j.neuron.2021.11.013. Epub 2021 Dec 3.
The claustrum, a subcortical nucleus forming extensive connections with the neocortex, has been implicated in sensory selection. Sensory-evoked claustrum activity is thought to modulate the neocortex's context-dependent response to sensory input. Recording from claustrum neurons while mice performed a tactile-visual sensory-selection task, we found that neurons in the anterior claustrum, including putative optotagged claustrocortical neurons projecting to the primary somatosensory cortex (S1), were rarely modulated by sensory input. Rather, they exhibited different types of direction-tuned motor responses. Furthermore, we found that claustrum neurons encoded upcoming movement during intertrial intervals and that pairs of claustrum neurons exhibiting synchronous firing were enriched for pairs preferring contralateral lick directions, suggesting that the activity of specific ensembles of similarly tuned claustrum neurons may modulate cortical activity. Chemogenetic inhibition of claustrocortical neurons decreased lick responses to inappropriate sensory stimuli. Altogether, our data indicate that the claustrum is integrated into higher-order premotor circuits recently implicated in decision-making.
屏状核是与新皮层广泛连接的皮层下核团，它与感觉选择有关。感觉诱发的屏状核活动被认为调节了新皮层对外来感觉输入的上下文相关反应。在小鼠进行触觉-视觉感觉选择任务时，我们记录了屏状核神经元的活动，发现在前屏状核的神经元，包括投射到初级体感皮层（S1）的假定光遗传学标记的屏状皮质神经元，很少被感觉输入调制。相反，它们表现出不同类型的定向调谐运动反应。此外，我们发现，在试验间间隔期间，屏状核神经元对即将到来的运动进行编码，并且表现出同步放电的对神经元对富含对相反侧舔方向的偏好，这表明特定的、调谐相似的屏状核神经元集合的活动可能调节皮质活动。屏状皮质神经元的化学遗传抑制降低了对不适当感觉刺激的舔反应。总的来说，我们的数据表明，屏状核被整合到最近被认为与决策相关的更高阶的运动前回路中。
