[HLA system and complications of the treatment of rheumatoid polyarthritis with D-penicillamine].

The data of the literature concerning the relationship between complications of D-penicillamine treatment and the HLA system are discussed. This relationship particularly concerns the renal complications which are associated with HLA antigens B8 and DR3, although this relation is not sufficiently strong to be used in practice in the indications for treatment with D-penicillamine.