Wang Qiyue, Xue Wu, Zhang Xiaoke, Jin Fang, Hahn James
Department of Computer Science, The George Washington University, USA.
Department of Statistics, The George Washington University, USA.
Comput Biol Med. 2022 Jan;140:105088. doi: 10.1016/j.compbiomed.2021.105088. Epub 2021 Nov 30.
Fat accumulation in the liver cells can increase the risk of cardiac complications and cardiovascular disease mortality. Therefore, a way to quickly and accurately detect hepatic steatosis is critically important. However, current methods, e.g., liver biopsy, magnetic resonance imaging, and computerized tomography scan, are subject to high cost and/or medical complications. In this paper, we propose a deep neural network to estimate the degree of hepatic steatosis (low, mid, high) using only body shapes. The proposed network adopts dilated residual network blocks to extract refined features of input body shape maps by expanding the receptive field. Furthermore, to classify the degree of steatosis more accurately, we create a hybrid of the center loss and cross entropy loss to compact intra-class variations and separate inter-class differences. We performed extensive tests on the public medical dataset with various network parameters. Our experimental results show that the proposed network achieves a total accuracy of over 82% and offers an accurate and accessible assessment for hepatic steatosis.
肝细胞中的脂肪堆积会增加心脏并发症和心血管疾病死亡率的风险。因此,一种快速准确检测肝脂肪变性的方法至关重要。然而,目前的方法,如肝活检、磁共振成像和计算机断层扫描,存在成本高和/或医疗并发症的问题。在本文中,我们提出了一种深度神经网络,仅使用身体形状来估计肝脂肪变性的程度(低、中、高)。所提出的网络采用扩张残差网络块,通过扩大感受野来提取输入身体形状图的精细特征。此外,为了更准确地对脂肪变性程度进行分类,我们创建了中心损失和交叉熵损失的混合损失,以紧凑类内变化并分离类间差异。我们使用各种网络参数在公共医学数据集上进行了广泛测试。我们的实验结果表明,所提出的网络总准确率超过82%,并为肝脂肪变性提供了准确且可及的评估。