年轻女性镰状细胞贫血患者卵巢储备功能减退。
Diminished ovarian reserve in young women with sickle cell anemia.
机构信息
Division of Hematology, Department of Medicine.
Department of Gynecology and Obstetrics.
出版信息
Blood. 2022 Feb 17;139(7):1111-1115. doi: 10.1182/blood.2021012756.
Abstract
Women with sickle cell anemia (SCA) have higher rates of diminished ovarian reserve (DOR) than age-matched controls. Pecker et al report a small study of patients with SCA that compares ovarian reserve in patients after stem cell transplant, on therapy with hydroxyurea (HU), and on supportive care. As expected, patients who received transplants have severe DOR. About one-third of patients on HU have DOR, while DOR was absent in patients on supportive care. Whether this reflects an impact of HU or is a biomarker of severe disease remains to be established in a larger study.
摘要
患有镰状细胞贫血症 (SCA) 的女性的卵巢储备功能减退 (DOR) 发生率高于同龄对照。Pecker 等人报告了一项针对 SCA 患者的小型研究，比较了干细胞移植后、羟基脲 (HU) 治疗中和支持性护理中的患者的卵巢储备情况。正如预期的那样，接受移植的患者有严重的 DOR。约三分之一的 HU 治疗患者有 DOR，而支持性护理的患者则没有 DOR。这是反映 HU 的影响还是严重疾病的生物标志物，尚需在更大的研究中确定。
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