RCandy：用于可视化细菌基因组中同源重组的 R 包。
RCandy: an R package for visualizing homologous recombinations in bacterial genomes.
机构信息
Parasites and Microbes Programme, Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK.
Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
出版信息
Bioinformatics. 2022 Feb 7;38(5):1450-1451. doi: 10.1093/bioinformatics/btab814.
SUMMARY
Homologous recombination is an important evolutionary process in bacteria and other prokaryotes, which increases genomic sequence diversity and can facilitate adaptation. Several methods and tools have been developed to detect genomic regions recently affected by recombination. Exploration and visualization of such recombination events can reveal valuable biological insights, but it remains challenging. Here, we present RCandy, a platform-independent R package for rapid, simple and flexible visualization of recombination events in bacterial genomes.
AVAILABILITY AND IMPLEMENTATION
RCandy is an R package freely available for use under the MIT license. It is platform-independent and has been tested on Windows, Linux and MacOSX. The source code comes together with a detailed vignette available on GitHub at https://github.com/ChrispinChaguza/RCandy.
SUPPLEMENTARY INFORMATION
Supplementary data are available at Bioinformatics online.
摘要
同源重组是细菌和其他原核生物中一个重要的进化过程，它增加了基因组序列的多样性，并能促进适应。已经开发了几种方法和工具来检测最近受到重组影响的基因组区域。探索和可视化这些重组事件可以揭示有价值的生物学见解，但这仍然具有挑战性。在这里，我们提出了 RCandy，这是一个用于快速、简单和灵活可视化细菌基因组中重组事件的平台独立的 R 包。
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