School of Pharmacy, Yancheng Teachers' University, Yancheng, China.
Nucleosides Nucleotides Nucleic Acids. 2022;41(1):85-96. doi: 10.1080/15257770.2021.2008433. Epub 2021 Dec 6.
In recent years, several case-control studies have explored the association between the rs7763881 locus polymorphism of the gene and cancer risk, however, the findings have been inconsistent. Therefore, a meta-analysis was conducted to clarify the association. Relevant case-control studies were obtained from CNKI, Embase, Web of Science and PubMed databases. RevMan software was used to perform data analysis. A total of 8 case-control studies containing 4036 cases and 5286 controls were included in the current meta-analysis. The overall analysis results showed no significant association between the rs7763881 locus polymorphism and cancer risk. However, stratified analysis based on cancer type showed that the rs7763881 locus polymorphism was associated with the decreased risk of hepatocellular cancer, colorectal cancer and esophageal cancer. In conclusion, the current findings suggest that the rs7763881 polymorphic loci located on the gene may serve as a biomarker for determining an individual's risk of hepatocellular cancer, colorectal cancer and esophageal cancer.
近年来，有几项病例对照研究探讨了基因 rs7763881 位点多态性与癌症风险之间的关系，但研究结果并不一致。因此，进行了荟萃分析以阐明这种关联。从中国知网、Embase、Web of Science 和 PubMed 数据库中获取相关的病例对照研究。使用 RevMan 软件进行数据分析。本荟萃分析共纳入 8 项病例对照研究，包含 4036 例病例和 5286 例对照。总体分析结果显示，rs7763881 位点多态性与癌症风险之间无显著关联。然而，基于癌症类型的分层分析显示，rs7763881 位点多态性与肝癌、结直肠癌和食管癌风险降低相关。总之，目前的研究结果表明，位于基因上的 rs7763881 多态性位点可能可作为确定个体肝癌、结直肠癌和食管癌风险的生物标志物。
