Lodz University of Technology, Institute of Applied Radiation Chemistry, Laboratory of Laser Molecular Spectroscopy, Wroblewskiego 15, 93-590 Lodz, Poland.
Lodz University of Technology, Institute of Applied Radiation Chemistry, Laboratory of Laser Molecular Spectroscopy, Wroblewskiego 15, 93-590 Lodz, Poland.
Spectrochim Acta A Mol Biomol Spectrosc. 2022 Mar 5;268:120667. doi: 10.1016/j.saa.2021.120667. Epub 2021 Nov 29.
Raman spectroscopy and Raman imaging are powerful techniques to monitor biochemical composition around blood vessel. The aim of this study was to understand the role of pro- and antiangiogenic factors in angiogenesis process. Raman imaging and Raman single spectrum measurements allow the diagnosis of cancer biochemical changes in blood vessel based on several biomarkers simultaneously. We have demonstrated that Raman imaging combined with statistical methods are useful to monitoring pro- and antiangiogenic factors responsible for angiogenesis process. In this work Raman markers of proangiogenic and antiangiogenic factors were identified based on their vibrational signatures. Obtained results can help understand how growing tumor create its vascular system.
拉曼光谱和拉曼成像是监测血管周围生化成分的强大技术。本研究的目的是了解促血管生成和抗血管生成因子在血管生成过程中的作用。拉曼成象和拉曼单谱测量允许基于几个生物标志物同时诊断血管中的癌症生化变化。我们已经证明，拉曼成象与统计方法相结合，可用于监测导致血管生成过程的促血管生成和抗血管生成因子。在这项工作中，基于其振动特征确定了促血管生成和抗血管生成因子的拉曼标记物。所得到的结果可以帮助理解生长中的肿瘤如何创建其血管系统。
