Biophotonics Research Unit, Leadon House, Gloucestershire Hospitals NHS Foundation Trust, Gloucester, UK GL1 3NN.
Analyst. 2009 Jun;134(6):1029-45. doi: 10.1039/b822130h. Epub 2009 Mar 23.
Vibrational spectroscopy techniques have demonstrated potential to provide non-destructive, rapid, clinically relevant diagnostic information. Early detection is the most important factor in the prevention of cancer. Raman and infrared spectroscopy enable the biochemical signatures from biological tissues to be extracted and analysed. In conjunction with advanced chemometrics such measurements can contribute to the diagnostic assessment of biological material. This paper also illustrates the complementary advantage of using Raman and FTIR spectroscopy technologies together. Clinical requirements are increasingly met by technological developments which show promise to become a clinical reality. This review summarises recent advances in vibrational spectroscopy and their impact on the diagnosis of cancer.
振动光谱技术已经证明具有提供非破坏性、快速、临床相关诊断信息的潜力。早期检测是预防癌症的最重要因素。拉曼和红外光谱使从生物组织中提取和分析生物化学特征成为可能。结合先进的化学计量学，这些测量可以有助于生物材料的诊断评估。本文还说明了同时使用拉曼和 FTIR 光谱技术的互补优势。技术的发展越来越满足临床需求，这些技术有望成为临床现实。本文综述了振动光谱技术的最新进展及其对癌症诊断的影响。
