Department of Cardiology I - Coronary and Peripheral Vascular Disease, Heart Failure, University Hospital Münster, Münster, Germany; Institutes of Molecular Genetics of the Czech Academy of Sciences, Prague, Czechia.
Department of Cardiology I - Coronary and Peripheral Vascular Disease, Heart Failure, University Hospital Münster, Münster, Germany.
Trends Mol Med. 2022 Jan;28(1):1-4. doi: 10.1016/j.molmed.2021.11.003. Epub 2021 Dec 2.
Recent studies emphasize the importance of low-density lipoprotein cholesterol (LDL-C) in altering the hematopoietic cell compartment of bone marrow and of high-density lipoprotein cholesterol (HDL-C) in inhibiting metabolic endotoxemia-induced inflammation. The data suggest that these lipoproteins may exert their inflammatory or anti-inflammatory roles by modulating innate immune memory. Targeting specific LDL-C and HDL-C subfractions could therefore potentially reduce the residual risk in hepatic and cardiometabolic disease.
最近的研究强调了低密度脂蛋白胆固醇（LDL-C）在改变骨髓造血细胞区室和高密度脂蛋白胆固醇（HDL-C）在抑制代谢性内毒素血症诱导的炎症方面的重要性。这些数据表明，这些脂蛋白可能通过调节先天免疫记忆发挥其炎症或抗炎作用。因此，靶向特定的 LDL-C 和 HDL-C 亚组分可能潜在地降低肝和代谢性心血管疾病的残余风险。
