一种测定头孢菌素的简单快速化学方法。
A simple and rapid chemical method for the determination of cephalosporins.
作者信息
Lübbe C, Shen Y Q, Demain A L
出版信息
Appl Biochem Biotechnol. 1986 Feb;12(1):31-5. doi: 10.1007/BF02798577.
PMID:3486633
Abstract
A simple and rapid chemical assay for cephalosporins is described. It is a simple modification of the colorimetric determination of penicillins in which the narrow spectrum beta-lactamase (penicillinase) is replaced by a broad spectrum beta-lactamase (cephalosporinase) produced by Enterobacter cloacae. The method can be used for assay of fermentation broths as well as for pure cephalosporins.
摘要
本文描述了一种简单快速的头孢菌素化学分析方法。它是比色法测定青霉素的一种简单改进，其中窄谱β-内酰胺酶（青霉素酶）被阴沟肠杆菌产生的广谱β-内酰胺酶（头孢菌素酶）所取代。该方法可用于发酵液的分析以及纯头孢菌素的分析。
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本文引用的文献
1
Automated colorimetric determination of penicillin in fermentation samples using a molybdoarsenic acid-mercuric chloride reagent.
Anal Chem. 1972 Apr 1;44(4):795-9. doi: 10.1021/ac60312a040.
2
Beta-lactamase assays.
Methods Enzymol. 1975;43:69-85. doi: 10.1016/0076-6879(75)43081-6.
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