SIRT1 基因多态性与类风湿关节炎。
Gene polymorphisms of SIRT1 in patients with rheumatoid arthritis.
机构信息
Department of Evidence-Based Medicine, Southwest Medical University, Luzhou, China.
Department of Orthopaedics, The Affiliated Hospital of Southwest Medical University, Luzhou, China.
出版信息
Int J Rheum Dis. 2022 Feb;25(2):210-217. doi: 10.1111/1756-185X.14257. Epub 2021 Dec 5.
AIM
Previous studies have shown that silent information regulator 1 (SIRT1) expression is elevated in rheumatoid arthritis (RA) patients. However, whether gene polymorphisms in SIRT1 gene associated with RA in a Chinese Han population remains to be discussed.
METHOD
In this case-control study, 529 RA patients and 700 healthy controls were selected, and association of 11 SIRT1 gene polymorphisms (rs12415800, rs3740051, rs932658, rs3740053, rs7895833, rs10509291, rs33957861, rs7069102, rs2273773, rs3818292, rs1467568) with RA susceptibility was evaluated.
RESULTS
Frequency of GA+GG genotype of rs3740051 in RA patients was significantly lower than that in healthy controls (P = .037). Frequencies of GC and GC+GG genotypes of rs7069102 were significantly lower than those in healthy controls (P = .036, P = .047). Frequencies of GA and GA+GG genotypes of rs1467568 were lower in RA patients as compared to those in healthy controls (P = .011, P = .013). For rs2273773, RA patients who carried the T allele had higher number of tender joints than patients who carried the C allele (P = .033). Other polymorphisms did not associate with RA risk.
CONCLUSION
The findings suggest that rs3740051, rs7069102 and rs1467568 variants in SIRT1 gene are related to RA susceptibility in a Chinese Han population.
目的
先前的研究表明，沉默信息调节因子 1（SIRT1）在类风湿关节炎（RA）患者中的表达水平升高。然而，SIRT1 基因中的基因多态性是否与中国汉族人群中的 RA 相关仍有待探讨。
方法
在这项病例对照研究中，选择了 529 名 RA 患者和 700 名健康对照者，评估了 11 个 SIRT1 基因多态性（rs12415800、rs3740051、rs932658、rs3740053、rs7895833、rs10509291、rs33957861、rs7069102、rs2273773、rs3818292、rs1467568）与 RA 易感性的关联。
结果
RA 患者 rs3740051 的 GA+GG 基因型频率明显低于健康对照组（P =.037）。rs7069102 的 GC 和 GC+GG 基因型频率明显低于健康对照组（P =.036，P =.047）。rs1467568 的 GA 和 GA+GG 基因型频率在 RA 患者中低于健康对照组（P =.011，P =.013）。对于 rs2273773，携带 T 等位基因的 RA 患者的压痛关节数多于携带 C 等位基因的患者（P =.033）。其他多态性与 RA 风险无关。
结论
研究结果表明，SIRT1 基因中的 rs3740051、rs7069102 和 rs1467568 变异与中国汉族人群的 RA 易感性有关。
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