Namdari Somayeh, Saadat Mostafa
Department of Biology, Shiraz University College of Sciences, Shiraz, Iran
J Turk Ger Gynecol Assoc. 2021 Dec 6;22(4):268-272. doi: 10.4274/jtgga.galenos.2021.2021.0005.
There is much evidence that oxidative stress is involved in the pathogenesis of preeclampsia (PE). A 50 bp insertion/deletion (Ins/Del) functional polymorphism in the promoter region of has been reported. Due to a total lack of data, the aim of this study was to investigate the association between the (Ins/Del) polymorphism and the risk of PE.
The current hospital-based case-control study included a total of 172 preeclamptic and 171 non-preeclamptic pregnancies. Genotyping was performed using the polymerase chain reaction method.
Statistical analysis revealed that the Del/Del genotype significantly correlated with susceptibility to PE [odds ratio (OR): 6.53, 95% confidence interval (CI): 1.43-29.7, p=0.015]. Since maternal body mass index, family history of PE in first degree relatives, and educational levels were statistically associated with the susceptibility to PE, further analyses were carried out in order to estimate the adjusted ORs. After adjustment for aforementioned variables, the Del/Del genotype increased the risk of PE (OR: 5.98, 95% CI: 1.21-29.5, p=0.028).
The 50 bp Ins/Del in promoter region of the gene could be an intriguing susceptibility factor for developing preeclampsia in Iranian Caucasians.
有大量证据表明氧化应激参与子痫前期（PE）的发病机制。已有报道称在 基因启动子区域存在一个50 bp的插入/缺失（Ins/Del）功能多态性。由于完全缺乏相关数据，本研究旨在探讨 基因（Ins/Del）多态性与PE风险之间的关联。
本次基于医院的病例对照研究共纳入172例子痫前期妊娠和171例非子痫前期妊娠。采用聚合酶链反应方法进行基因分型。
统计分析显示，Del/Del基因型与PE易感性显著相关[比值比（OR）：6.53，95%置信区间（CI）：1.43 - 29.7，p = 0.015]。由于孕妇体重指数、一级亲属中PE家族史以及教育水平与PE易感性在统计学上相关，因此进行了进一步分析以估计校正后的OR值。在对上述变量进行校正后，Del/Del基因型增加了PE风险（OR：5.98，95% CI：1.21 - 29.5，p = 0.028）。
基因启动子区域的50 bp Ins/Del可能是伊朗高加索人发生子痫前期的一个有趣的易感因素。
