Climer Leslie K, Hornak Aubrey J, Murtha Kaitlin, Yang Yang, Cox Andrew M, Simpson Preston L, Le Andy, Simmons Dwayne D
Department of Biology, Baylor University, Waco, TX, United States.
Department of Psychology and Neuroscience, Baylor University, Waco, TX, United States.
Front Aging Neurosci. 2021 Nov 15;13:749729. doi: 10.3389/fnagi.2021.749729. eCollection 2021.
Ca signaling is a major contributor to sensory hair cell function in the cochlea. Oncomodulin (OCM) is a Ca binding protein (CaBP) preferentially expressed in outer hair cells (OHCs) of the cochlea and few other specialized cell types. Here, we expand on our previous reports and show that OCM delays hearing loss in mice of two different genetic backgrounds: CBA/CaJ and C57Bl/6J. In both backgrounds, genetic disruption of leads to early progressive hearing loss as measured by auditory brainstem response (ABR) and distortion product otoacoustic emission (DPOAE). In both strains, loss of reduced hearing across lifetime (hearing span) by more than 50% relative to wild type (WT). Even though the two WT strains have very different hearing spans, OCM plays a considerable and similar role within their genetic environment to regulate hearing function. The accelerated age-related hearing loss (ARHL) of the KO illustrates the importance of Ca signaling in maintaining hearing health. Manipulation of OCM and Ca signaling may reveal important clues to the systems of function/dysfunction that lead to ARHL.
钙信号传导是耳蜗中感觉毛细胞功能的主要贡献因素。癌调蛋白（OCM）是一种钙结合蛋白（CaBP），优先表达于耳蜗的外毛细胞（OHC）和其他少数特殊细胞类型中。在此，我们扩展了之前的报告，并表明OCM可延缓两种不同遗传背景小鼠（CBA/CaJ和C57Bl/6J）的听力损失。在这两种背景下，通过听觉脑干反应（ABR）和畸变产物耳声发射（DPOAE）测量，基因破坏会导致早期进行性听力损失。在这两种品系中，相对于野生型（WT），基因缺失导致终生听力（听力跨度）下降超过50%。尽管两种野生型品系的听力跨度差异很大，但OCM在其遗传环境中发挥着相当且相似的作用来调节听力功能。OCM基因敲除小鼠加速的年龄相关性听力损失（ARHL）说明了钙信号传导在维持听力健康中的重要性。对OCM和钙信号传导的调控可能揭示导致ARHL的功能/功能障碍系统的重要线索。
