Wang Yanyu, Wei Shan, Zhou Rong, Shang Suhang, Dang Liangjun, Gao Ling, Chen Chen, Huo Kang, Wang Jingyi, Wang Jin, Qu Qiumin
Department of Neurology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Huyi Hospital of Traditional Chinese Medicine, Xi'an, China.
Front Aging Neurosci. 2021 Nov 19;13:761886. doi: 10.3389/fnagi.2021.761886. eCollection 2021.
The relationships between blood lipid levels and obesity and cognitive impairment have not been fully determined. Considering that the lipid accumulation product (LAP) is a composite index of blood lipid levels and obesity, we investigated the relationships between LAP levels at baseline and cognitive decline over 4 years. A total of 983 subjects (≥40 years) from a longitudinal cohort in a village of Xi'an, China, who completed the baseline survey were followed-up for 4 years. All participants underwent face-to-face interviews and cognitive assessments at baseline and at the 4-year follow-up. The Mini-Mental State Examination (MMSE) was used to assess cognitive function, and an MMSE score dropping ≥ 2 points from baseline was defined as cognitive decline. The relationships between LAP and cognitive decline were analyzed by linear regression models. During the 4-year follow-up, 172 patients exhibited cognitive decline (17.5%). Univariate analysis showed that the rate of change in MMSE score was significantly different between the low-LAP group and the high-LAP group ( = -2.26, = 0.024). Multiple linear regression indicated that a high LAP was positively associated with cognitive decline (β = 0.564, = 0.012). Stratified multivariate analysis showed that LAP was positively associated with cognitive decline in the normal blood pressure female subgroup (β = 1.29, = 0.002) but not in the high blood pressure group or the male group. High LAP is associated with cognitive decline in females with normal blood pressure but not in those with high blood pressure or males. This indicates that the relationships between blood lipid levels and obesity and cognitive impairment may be affected by blood pressure and sex.
血脂水平与肥胖及认知障碍之间的关系尚未完全明确。鉴于脂质蓄积产物（LAP）是血脂水平和肥胖的综合指标，我们研究了基线时LAP水平与4年期间认知功能衰退之间的关系。来自中国西安一个村庄的纵向队列中，共有983名年龄≥40岁且完成基线调查的受试者接受了4年的随访。所有参与者在基线和4年随访时均接受了面对面访谈和认知评估。采用简易精神状态检查表（MMSE）评估认知功能，MMSE评分较基线下降≥2分被定义为认知功能衰退。通过线性回归模型分析LAP与认知功能衰退之间的关系。在4年随访期间，172例患者出现认知功能衰退（17.5%）。单因素分析显示，低LAP组和高LAP组的MMSE评分变化率存在显著差异（=-2.26，=0.024）。多元线性回归表明，高LAP与认知功能衰退呈正相关（β=0.564，=0.012）。分层多因素分析显示，LAP与正常血压女性亚组的认知功能衰退呈正相关（β=1.29，=0.002），但在高血压组或男性组中并非如此。高LAP与血压正常女性的认知功能衰退相关，但与高血压女性或男性无关。这表明血脂水平与肥胖及认知障碍之间的关系可能受血压和性别的影响。
