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白细胞介素1介导的辐射防护分析。

Analysis of interleukin 1 mediated radioprotection.

作者信息

Manori I, Kushilevsky A, Weinstein Y

出版信息

Clin Exp Immunol. 1986 Mar;63(3):526-32.

PMID:3486730
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1577567/
Abstract

The potential value of interleukin 1 (IL-1) containing supernatants as a radioprotective agent was evaluated. It was found that the response of irradiated thymocytes to mitogens was partially restored if IL-1 containing supernatants was included in the culture medium immediately after irradiation. A delay of 24 h in the addition of IL-1 and mitogen abrogated the radioprotection effect. Under the same conditions IL-2 containing supernatants were effective, suggesting that the dose modifying effect of IL-1 acts through induction of IL-2 elaboration. The results of the present study may be important in cases where it is necessary to restore depressed immune response resulting from irradiation accidents or radiotherapy.

摘要

评估了含白细胞介素1（IL-1）的上清液作为辐射防护剂的潜在价值。研究发现，如果在照射后立即将含IL-1的上清液加入培养基中，受照射胸腺细胞对有丝分裂原的反应可部分恢复。添加IL-1和有丝分裂原延迟24小时会消除辐射防护效果。在相同条件下，含IL-2的上清液也有效，这表明IL-1的剂量调节作用是通过诱导IL-2的分泌来实现的。本研究结果对于因辐射事故或放射治疗导致免疫反应抑制而需要恢复的情况可能具有重要意义。

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引用本文的文献

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Characterization of mouse thymocyte subpopulations by the enzymatic marker 20-alpha-hydroxysteroid dehydrogenase: differential responses to IL-1 and IL-2.用酶标记物20-α-羟基类固醇脱氢酶对小鼠胸腺细胞亚群进行表征：对白细胞介素-1和白细胞介素-2的不同反应。
Clin Exp Immunol. 1987 Dec;70(3):578-84.

本文引用的文献

1
The radiobiology of mammalian cells.
Semin Oncol. 1981 Mar;8(1):3-17.
2
Interleukin 2: a class of T cell growth factors.白细胞介素2：一类T细胞生长因子。
Immunol Rev. 1980;51:257-78. doi: 10.1111/j.1600-065x.1980.tb00324.x.
3
Lymphocyte activating factor promotes T-cell growth factor production by cloned murine lymphoma cells.淋巴细胞激活因子可促进克隆的鼠淋巴瘤细胞产生T细胞生长因子。
Nature. 1980 Oct 30;287(5785):853-5. doi: 10.1038/287853a0.
4
Radiosensitivity of isolated subsets of human lymphocytes (E+, OKT4+, OKT8+): protective role of monocytes and monokines.人淋巴细胞分离亚群（E+、OKT4+、OKT8+）的放射敏感性：单核细胞和单核因子的保护作用。
Clin Exp Immunol. 1984 Nov;58(2):453-61.
5
Potentiation of the T-lymphocyte response to mitogens. II. The cellular source of potentiating mediator(s).T淋巴细胞对丝裂原反应的增强作用。II. 增强介质的细胞来源。
J Exp Med. 1972 Jul 1;136(1):143-55. doi: 10.1084/jem.136.1.143.
6
Letter: The lymphocyte response to phytohaemagglutinin after in vitro irradiation.信件：体外照射后淋巴细胞对植物血凝素的反应。
Br J Radiol. 1974 May;47(557):297. doi: 10.1259/0007-1285-47-557-297-b.
7
The surviving lymphocyte "in vitro" after radiation stress: a biologic dosimeter.辐射应激后存活的“体外”淋巴细胞：一种生物剂量计。
J Can Assoc Radiol. 1973 Mar;24(1):51-61.
8
Effect of radiation on the production of interleukins and T-lymphocyte activities.
J Natl Cancer Inst. 1985 Jun;74(6):1215-21.
9
T cell growth factor: parameters of production and a quantitative microassay for activity.T细胞生长因子：产生参数及活性的定量微量测定法。
J Immunol. 1978 Jun;120(6):2027-32.

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