Denis Dan, Bottary Ryan, Cunningham Tony J, Zeng Shengzi, Daffre Carolina, Oliver Kaitlyn L, Moore Kylie, Gazecki Samuel, Kram Mendelsohn Augustus, Martinez Uriel, Gannon Karen, Lasko Natasha B, Pace-Schott Edward F
Department of Psychology, University of Notre Dame, Notre Dame, IN, United States.
Department of Psychology and Neuroscience, Boston College, Chestnut Hill, MA, United States.
Front Psychiatry. 2021 Nov 19;12:766647. doi: 10.3389/fpsyt.2021.766647. eCollection 2021.
Sleep disturbances are common in post-traumatic stress disorder (PTSD), although which sleep microarchitectural characteristics reliably classify those with and without PTSD remains equivocal. Here, we investigated sleep microarchitectural differences (i.e., spectral power, spindle activity) in trauma-exposed individuals that met ( = 45) or did not meet ( = 52) criteria for PTSD and how these differences relate to post-traumatic and related psychopathological symptoms. Using ecologically-relevant home sleep polysomnography recordings, we show that individuals with PTSD exhibit decreased beta spectral power during NREM sleep and increased fast sleep spindle peak frequencies. Contrary to prior reports, spectral power in the beta frequency range (20.31-29.88 Hz) was associated with reduced PTSD symptoms, reduced depression, anxiety and stress and greater subjective ability to regulate emotions. Increased fast frequency spindle activity was not associated with individual differences in psychopathology. Our findings may suggest an adaptive role for beta power during sleep in individuals exposed to a trauma, potentially conferring resilience. Further, we add to a growing body of evidence that spindle activity may be an important biomarker for studying PTSD pathophysiology.
睡眠障碍在创伤后应激障碍（PTSD）中很常见，尽管哪些睡眠微结构特征能够可靠地区分患有和未患有PTSD的个体仍不明确。在此，我们调查了符合（n = 45）或不符合（n = 52）PTSD标准的创伤暴露个体的睡眠微结构差异（即频谱功率、纺锤波活动），以及这些差异与创伤后及相关精神病理症状的关系。使用与生态相关的家庭睡眠多导睡眠图记录，我们发现患有PTSD的个体在非快速眼动睡眠期间β频谱功率降低，快速睡眠纺锤波峰值频率增加。与先前的报告相反，β频率范围（20.31 - 29.88 Hz）的频谱功率与PTSD症状减轻、抑郁、焦虑和压力减轻以及更强的主观情绪调节能力相关。快速频率纺锤波活动增加与精神病理学的个体差异无关。我们的研究结果可能表明，在遭受创伤的个体中，睡眠期间的β功率具有适应性作用，可能赋予恢复力。此外，我们补充了越来越多的证据，表明纺锤波活动可能是研究PTSD病理生理学的重要生物标志物。
