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哥伦比亚样本中行为变异型额颞叶痴呆的精神科误诊

The Psychiatric Misdiagnosis of Behavioral Variant Frontotemporal Dementia in a Colombian Sample.

作者信息

Zapata-Restrepo Lina, Rivas Juan, Miranda Carlos, Miller Bruce L, Ibanez Agustín, Allen Isabel E, Possin Katherine

机构信息

Global Brain Health Institute, University of California, San Francisco, San Francisco, CA, United States.

Trinity College Dublin, Dublin, Ireland.

出版信息

Front Neurol. 2021 Nov 15;12:729381. doi: 10.3389/fneur.2021.729381. eCollection 2021.

Abstract

To describe the demographic characteristics, initial psychiatric diagnoses, and the time to reach a diagnosis of probable behavioral variant frontotemporal dementia (bvFTD) in a public psychiatric hospital in Cali, Colombia. We retrospectively reviewed the medical records of 28 patients who were diagnosed with probable bvFTD based on a multidisciplinary evaluation that included a structural MRI, neuropsychological testing, functional assessment, and neurological exam. Prior to this evaluation, all patients were evaluated by a psychiatrist as part of their initial consultation at the hospital. The initial consultation included the Neuropsychiatric Inventory and diagnoses based on the DSM-V. Demographics, clinical features, and initial psychiatric misdiagnoses were extracted from clinical records and summarized in the full sample and by gender. The study sample had a mean education of 10.0 years (SD = 4.9) and 68.0% were female. In the full sample, 28.6% were initially diagnosed with dementia, and 71.4% with a psychiatric disorder. The psychiatric diagnosis at initial consultation differed by gender. Women were most likely to be diagnosed with depression (26.3%) or bipolar disorder (26.3%), while the men were most likely to be diagnosed with anxiety (33.3%) or a psychotic disorder (22.2%). Psychotic symptoms were common (delusions, 60.7% and hallucinations, 39.3%), and the pattern of neuropsychiatric symptoms did not differ by gender. This is one of few case series of bvFTD in a Colombian population, where bvFTD is a recognizable and prevalent disorder. In this psychiatric hospital, the majority of patients with bvFTD were initially diagnosed with a primary psychiatric condition. There was a gender difference in psychiatric diagnosis, but not in neuropsychiatric symptoms. In this sample, the rate of psychiatric misdiagnosis, as well as the psychotic symptoms, were higher compared to rates described in other countries. These results highlight the need for interventions to improve bvFTD diagnosis in under-represented populations.

摘要

描述哥伦比亚卡利市一家公立精神病医院中可能患有行为变异型额颞叶痴呆(bvFTD)患者的人口统计学特征、初始精神科诊断以及确诊时间。我们回顾性分析了28例经多学科评估确诊为可能的bvFTD患者的病历,评估包括结构磁共振成像、神经心理学测试、功能评估和神经学检查。在此评估之前,所有患者在医院初诊时均由精神科医生进行评估。初诊包括神经精神科问卷以及基于《精神疾病诊断与统计手册》第五版(DSM-V)的诊断。从临床记录中提取人口统计学、临床特征和初始精神科误诊情况,并在整个样本以及按性别分类的样本中进行总结。研究样本的平均受教育年限为10.0年(标准差 = 4.9),68.0%为女性。在整个样本中,28.6%最初被诊断为痴呆,71.4%被诊断为精神障碍。初诊时的精神科诊断因性别而异。女性最常被诊断为抑郁症(26.3%)或双相情感障碍(26.3%),而男性最常被诊断为焦虑症(33.3%)或精神病性障碍(22.2%)。精神病性症状很常见(妄想,60.7%;幻觉,39.3%),且神经精神症状模式无性别差异。这是哥伦比亚人群中为数不多的bvFTD病例系列之一,其中bvFTD是一种可识别且普遍存在的疾病。在这家精神病医院,大多数bvFTD患者最初被诊断为原发性精神疾病。精神科诊断存在性别差异,但神经精神症状无性别差异。在这个样本中,精神科误诊率以及精神病性症状发生率高于其他国家报道的发生率。这些结果凸显了在代表性不足的人群中改善bvFTD诊断的干预措施的必要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/33b5/8634474/d36d64cbc4ff/fneur-12-729381-g0001.jpg

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