Marshall I, Al-Kazwini S J, Roberts P M, Shepperson N B, Adams M, Craig R K
Eur J Pharmacol. 1986 Apr 16;123(2):207-16. doi: 10.1016/0014-2999(86)90661-8.
In the anaesthetised rat, human and rat CGRP (calcitonin gene-related peptide) which differ by 4 out of 37 amino acids, when given intravenously, lowered blood pressure and increased heart rate. The effects of human CGRP were unaltered by either propranolol or by mepyramine plus cimetidine. In the rat isolated perfused heart the peptides decreased coronary perfusion pressure and evoked a tachycardia. The latter effect was not seen in the rabbit isolated heart, although human CGRP increased coronary flow. The two peptides were equipotent at increasing the rate and force of contraction in the rat isolated right atrium, effects unaltered by propranolol. In the guinea-pig isolated atrium, rat CGRP was 10 times as potent as a chronotropic agent than as an inotrope, unlike human CGRP which was equipotent. In conclusion, human and rat CGRP probably acted directly on the cardiovascular system to produce their qualitatively similar effects.
在麻醉大鼠中，人降钙素基因相关肽（CGRP）和大鼠CGRP（37个氨基酸中有4个不同）静脉注射时，可降低血压并加快心率。心得安或甲氧苄胺加西咪替丁均不改变人CGRP的作用。在大鼠离体灌流心脏中，这些肽可降低冠状动脉灌注压并引起心动过速。尽管人CGRP可增加冠状动脉血流量，但在兔离体心脏中未观察到后一种效应。这两种肽在增加大鼠离体右心房收缩速率和力量方面等效，心得安不改变这些效应。在豚鼠离体心房中，大鼠CGRP作为变时剂的效力是变力剂的10倍，而人CGRP则等效。总之，人CGRP和大鼠CGRP可能直接作用于心血管系统以产生定性相似的效应。
