Nunan T O, Compston J E, Tonge C
Digestion. 1986;34(1):9-14. doi: 10.1159/000199304.
A forearm counter and double-isotope technique were used to measure intestinal calcium absorption in 21 patients after jejuno-ileal bypass for obesity or small intestinal resection. In all but 2 patients calcium absorption was below the normal range for 10 male controls. 3 weeks treatment with 1-alpha-hydroxyvitamin D, 1 microgram b.d., or 1,25-dihydroxyvitamin D, 1 microgram b.d., was associated with significant increases in absorption whereas 3 weeks treatment with 24,25-dihydroxyvitamin D had no effect. This study demonstrates that oral 1,25-dihydroxyvitamin D or 1-alpha-hydroxyvitamin D are effective in increasing calcium absorption.
采用前臂计数器和双同位素技术，对21例因肥胖行空肠回肠旁路手术或小肠切除术后的患者进行肠道钙吸收测量。除2例患者外，其余患者的钙吸收均低于10名男性对照的正常范围。每天两次服用1微克1-α-羟维生素D或1,25-二羟维生素D进行3周治疗，可使钙吸收显著增加，而每天两次服用1微克24,25-二羟维生素D进行3周治疗则无效果。本研究表明，口服1,25-二羟维生素D或1-α-羟维生素D可有效增加钙吸收。
