Baumann R, Volk M, Taubert H D
Geburtshilfe Frauenheilkd. 1986 Apr;46(4):234-6. doi: 10.1055/s-2008-1035905.
This is a report on the first use of a fibrin adhesive in microsurgical refertilisation. During the period between 4.4. 1984 and 11.11. 1985 a total number of 17 women were operated on with the additional use of this fibrin adhesive. In the first group, operated on between 4.4. 1984 and 14.11. 1984, three pregnancies have occurred so far. On 6.4. 1985 the first patient of this group gave birth to a boy weighing 3050 gr. To our knowledge this is the first delivery world-wide that was effected with the additional use of fibrin adhesive. Laparoscopy of tube function of a further patient in this group who had not become pregnant after 12 months revealed normal anatomical conditions in the region of the refertilised tube as well as perfect patency. Two cases of intrauterine pregnancy are known in another group of 6 women operated on between 13.2. 1985 and 15.5. 1985. In five patients the follow-up period is less than 4 months, and hence these have been excluded from evaluation. No ectopic pregnancies are known so far. We believe we can sum up as follows in respect of preliminary results: Additional use of fibrin adhesive in the refertilisation of fallopian tubes will not result in enhanced risk of renewed closure. It will be possible to develop suture-free techniques of anastomosis after appropriate development. Operation times get shorter by using fibrin adhesive and the stress exercised on the patient by anaesthesia is reduced. There does not seem to be any enhanced risk of ectopic pregnancy.
这是一篇关于纤维蛋白粘合剂在显微外科再通术中首次应用的报告。在1984年4月4日至1985年11月11日期间,共有17名女性在使用这种纤维蛋白粘合剂的辅助下接受了手术。第一组在1984年4月4日至1984年11月14日期间接受手术,到目前为止已有3例怀孕。1985年4月6日,该组的第一名患者产下一名体重3050克的男婴。据我们所知,这是全球首例在使用纤维蛋白粘合剂辅助下实现的分娩。该组中另一名在12个月后未怀孕的患者,其输卵管功能的腹腔镜检查显示,再通输卵管区域的解剖结构正常,通畅性良好。在1985年2月13日至1985年5月15日期间接受手术的另一组6名女性中,已知有2例宫内妊娠。5名患者的随访期不到4个月,因此被排除在评估之外。到目前为止,尚未发现异位妊娠病例。就初步结果而言,我们认为可以总结如下:在输卵管再通术中额外使用纤维蛋白粘合剂不会增加再次堵塞的风险。经过适当发展,有可能开发出无需缝合的吻合技术。使用纤维蛋白粘合剂可缩短手术时间,并减轻麻醉对患者造成的压力。似乎不存在异位妊娠风险增加的情况。