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腹膜巨噬细胞的呈递：抗体-抗原复合物的调节作用

Presentation by peritoneal macrophages: modulation by antibody-antigen complexes.

作者信息

Perkins K A, Chain B M

出版信息

Immunology. 1986 May;58(1):15-21.

PMID:3486817
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1452616/
Abstract

The effects of immune complex formation on presentation was studied. Immune complexes between an IgG2a monoclonal anti-DNP antibody and TNP-KLH were produced, and the presentation of the carrier molecule by peritoneal macrophages to KLH-primed T cells was monitored. Complex formation was found to enhance the proliferative response of the T cells. This enhancement was specific, was not mediated by lymphokine release, and required antibody with an intact Fc portion. The significance of these results in terms of immune regulation and antigen presentation is discussed.

摘要

研究了免疫复合物形成对呈递的影响。制备了IgG2a单克隆抗二硝基苯酚（DNP）抗体与三硝基苯酚-钥孔戚血蓝蛋白（TNP-KLH）之间的免疫复合物，并监测了腹腔巨噬细胞将载体分子呈递给经钥孔戚血蓝蛋白（KLH）致敏的T细胞的过程。发现复合物形成增强了T细胞的增殖反应。这种增强是特异性的，不是由淋巴因子释放介导的，并且需要具有完整Fc部分的抗体。讨论了这些结果在免疫调节和抗原呈递方面的意义。

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