Su Wei-Ming, Gu Xiao-Jing, Hou Yan-Bing, Zhang Ling-Yu, Cao Bei, Ou Ru-Wei, Wu Ying, Chen Xue-Ping, Song Wei, Zhao Bi, Shang Hui-Fang, Chen Yong-Ping
Department of Neurology, West China Hospital, Sichuan University, Chengdu, China.
Laboratory of Neurodegenerative Disorders, West China Hospital, Sichuan University, Chengdu, China.
Front Genet. 2021 Nov 18;12:765833. doi: 10.3389/fgene.2021.765833. eCollection 2021.
The association between inflammation and neurodegeneration has long been observed in parkinson's disease (PD) and multiple system atrophy (MSA). Previous genome-wide association studies (GWAS) and meta-analyses have identified several risk loci in inflammation-associated genes associated with PD. To investigate whether polymorphisms in some inflammation-associated genes could modulate the risk of developing PD and MSA in a Southwest Chinese population. A total of 2,706 Chinese subjects comprising 1340 PD, 483 MSA and 883 healthy controls were recruited in the study. Three polymorphisms (rs2074404 GG/GT/TT, rs17425622 CC/CT/TT, rs34043159 CC/CT/TT) in genes linked to inflammation in all the subjects were genotyped by using the Sequenom iPLEX Assay. The allele G of rs2074404 can increase risk on PD (OR: 1.048, 95% CI: 1.182-1.333, = 0.006), exclusively in the LOPD subgroup (OR: 1.166, 95% CI:1.025-1.327, = 0.019), but not in EOPD or MSA. And the recessive model analysis also demonstrated an increased PD risk in GG genotype of this locus (OR = 1.331, = 0.007). However, no significant differences were observed in the genotype distributions and alleles of rs17425622 and rs34043159 between the PD patients and controls, between the MSA patients and controls, or between subgroups of PD or MSA and controls. Our results suggested the allele G of rs2074404 have an adverse effect on PD and particularly, on the LOPD subgroup among a Chinese population.
炎症与神经退行性变之间的关联在帕金森病（PD）和多系统萎缩（MSA）中早已被观察到。先前的全基因组关联研究（GWAS）和荟萃分析已经在与PD相关的炎症相关基因中确定了几个风险位点。为了研究某些炎症相关基因中的多态性是否会调节中国西南人群患PD和MSA的风险。本研究共招募了2706名中国受试者，包括1340名PD患者、483名MSA患者和883名健康对照。使用Sequenom iPLEX检测法对所有受试者中与炎症相关基因的三个多态性（rs2074404 GG/GT/TT、rs17425622 CC/CT/TT、rs34043159 CC/CT/TT）进行基因分型。rs2074404的等位基因G可增加患PD的风险（OR：1.048，95%CI：1.182 - 1.333，P = 0.006），仅在晚发型帕金森病（LOPD）亚组中（OR：1.166，95%CI：1.025 - 1.327，P = 0.019），而在早发型帕金森病（EOPD）或MSA中则不然。隐性模型分析也表明该位点的GG基因型患PD的风险增加（OR = 1.331，P = 0.007）。然而，在PD患者与对照之间、MSA患者与对照之间，或PD或MSA亚组与对照之间，rs17425622和rs34043159的基因型分布和等位基因未观察到显著差异。我们的结果表明，rs2074404的等位基因G对PD有不良影响，特别是对中国人群中的LOPD亚组。
