Sun Xifeng, Lu Yi, Zhu Hongxia, Li Rui, Zhang Donghua, Pang Kunfang
Department of Clinical Laboratory, Weifang People's Hospital, Weifang 261041, China.
Sterilization Supply Room, Qingdao Eighth People's Hospital, Qingdao 266000, China.
Evid Based Complement Alternat Med. 2021 Nov 26;2021:9286905. doi: 10.1155/2021/9286905. eCollection 2021.
To observe the effects of psychological intervention on the perioperative quality of life and serum prostate-specific antigen (PSA) and free PSA (FPSA) levels in patients with prostate cancer treated with integrated traditional Chinese and Western medicine.
A total of 208 prostate cancer patients were selected and randomly divided into a study group with 104 cases and a control group with 104 cases. The control group received a plan of basic nursing combined with integrated traditional Chinese and Western medicine, and the study group received psychological intervention on the basis of the control group. Negative emotion, pain degree, quality of life, maximum urine flow rate, residual urine volume, International Prostate Symptom Score (IPSS), and incidence of adverse reactions were compared between the two groups before and after the treatment. The levels of PSA and FPSA and the long-term efficacy of the two groups of patients before and after treatment were compared.
After nursing, Hamilton Anxiety Scale (HAMA) score, Hamilton Depression Scale (HAMD) score, pain degree, maximum urine flow rate, residual urine volume, IPSS score, emotional function, social function, role function, and physical function scores of patients in two groups were decreased, and the decrease was more significant in the study group. After treatment, serum PSA and FPSA levels in the study group were obviously lower than those in the control group. The two-year cumulative survival rate of the study group was higher than that of the control group. There was no significant difference in the cognitive function score and incidence of adverse reactions between the two groups.
Psychological intervention combined with traditional Chinese and Western medicine in the treatment of prostate cancer can effectively improve the patient's psychological state, reduce the degree of pain in patients, improve the therapeutic effect and the quality of life of patients, and significantly reduce serum PSA and FPSA levels, which could lead to a prolonged life.
观察心理干预对中西医结合治疗的前列腺癌患者围手术期生活质量及血清前列腺特异性抗原（PSA）和游离前列腺特异性抗原（FPSA）水平的影响。
选取208例前列腺癌患者，随机分为研究组104例和对照组104例。对照组接受基础护理联合中西医结合治疗方案，研究组在对照组基础上接受心理干预。比较两组治疗前后的负面情绪、疼痛程度、生活质量、最大尿流率、残余尿量、国际前列腺症状评分（IPSS）及不良反应发生率。比较两组患者治疗前后的PSA和FPSA水平及远期疗效。
护理后，两组患者的汉密尔顿焦虑量表（HAMA）评分、汉密尔顿抑郁量表（HAMD）评分、疼痛程度、最大尿流率、残余尿量、IPSS评分、情绪功能、社会功能、角色功能及躯体功能评分均降低，且研究组降低更显著。治疗后，研究组血清PSA和FPSA水平明显低于对照组。研究组两年累积生存率高于对照组。两组认知功能评分及不良反应发生率比较差异无统计学意义。
心理干预联合中西医结合治疗前列腺癌可有效改善患者心理状态，减轻患者疼痛程度，提高治疗效果及患者生活质量，显著降低血清PSA和FPSA水平，延长患者生命。
