Enhanced induction by X-irradiation of DNA double-strand breakage in mitotic as compared with S-phase V79 cells.
作者信息
Radford I R, Broadhurst S
出版信息
Int J Radiat Biol Relat Stud Phys Chem Med. 1986 Jun;49(6):909-14. doi: 10.1080/09553008514553141.
PMID:3486848
Abstract
A marked enhancement of X-ray-induced DNA double-strand breakage was demonstrated for mitotic Chinese hamster (V79) cells compared with S-phase cells or asynchronous cultures, which can explain the high radiosensitivity of mitotic cells. However, mitotic cells required twice the level of DNA double-strand breakage to produce a lethal lesion of that required for S-phase or asynchronous cells, suggesting that repair in mitotic cells is less error prone.
摘要
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