Fortin Marie-Chantal, Gill John, Allard Julie, Ballesteros Gallego Fabián, Gill Jagbir
Centre de recherche du Centre hospitalier de l'Université de Montréal, QC, Canada.
Canadian Donation and Transplantation Research Program, Edmonton, AB, Canada.
Can J Kidney Health Dis. 2021 Nov 25;8:20543581211058932. doi: 10.1177/20543581211058932. eCollection 2021.
Compatible pair participation in kidney paired donation (KPD) may increase the likelihood of finding suitable matches for all registered pairs. Retrospective studies have shown variable enthusiasm for participating in KPD in compatible pairs.
The study objective was to gather potential living donor (PLD) and transplant candidate (TC) perspectives on compatible pair participation in KPD.
Surveys and qualitative interviews.
Three transplant programs in Canada: Centre hospitalier de l'Université de Montréal in Montreal (Québec), Vancouver General Hospital, and St. Paul's Hospital in Vancouver (British Columbia).
Both PLDs and TCs undergoing evaluation for donation/transplantation between 2016 and 2018 at 3 transplant programs in Canada.
Descriptive statistical analysis was performed for the results of the survey and thematic and content analysis method was used for the content of the qualitative interviews.
A total of 116 PLDs and 111 TCs completed surveys and an additional 18 PLDs and 17 TCs underwent semi-directed interviews. Of those surveyed, 61.2% of PLDs and 76.6% of TCs reported a willingness to participate in KPD as a compatible pair. The possibility of a more optimally matched kidney for the TC and policies ensuring prioritization of the TC for repeat transplantation in the event of early graft failure increased willingness to participate in KPD. Major concerns expressed during the interviews included the desire to retain the emotional bond of directed donation, the fear of chain breaks or donor reneging, delays in transplantation, and additional travel associated with participation in KPD.
The limitations of this study are that it was conducted in only 3 Canadian transplant programs and that the interviews and surveys were in French and in English. As a consequence, the results may not be reflective of the views of individuals not living in these 2 provinces and from ethnic minority populations.
Most of the compatible PLDs and TCs surveyed were willing to participate in KPD. Ensuring timely transplantation and a more optimal match for TCs and offering a policy of reciprocity to ensure timely repeat transplantation for compatible recipients if their allograft fails post KPD transplant may further increase compatible pair participation in KPD.
在肾脏配对捐赠（KPD）中，匹配对参与可能会增加为所有登记对找到合适配型的可能性。回顾性研究表明，匹配对参与KPD的积极性各不相同。
本研究的目的是收集潜在活体供体（PLD）和移植受者候选人（TC）对匹配对参与KPD的看法。
调查和定性访谈。
加拿大的三个移植项目：蒙特利尔大学中心医院（位于魁北克省蒙特利尔）、温哥华总医院以及温哥华圣保罗医院（位于不列颠哥伦比亚省）。
2016年至2018年期间在加拿大三个移植项目中接受捐赠/移植评估的PLD和TC。
对调查结果进行描述性统计分析，对定性访谈内容采用主题和内容分析方法。
共有116名PLD和111名TC完成了调查，另有18名PLD和17名TC接受了半定向访谈。在接受调查的人中，61.2%的PLD和76.6%的TC表示愿意作为匹配对参与KPD。为TC提供更优匹配肾脏的可能性以及确保在早期移植物失败时TC优先接受再次移植的政策增加了参与KPD的意愿。访谈中表达的主要担忧包括希望保留定向捐赠的情感纽带、担心链条中断或供体反悔、移植延迟以及参与KPD带来的额外行程。
本研究的局限性在于仅在加拿大的三个移植项目中进行，且访谈和调查使用法语和英语。因此，结果可能无法反映非居住在这两个省份的个人以及少数族裔人群的观点。
大多数接受调查的匹配PLD和TC愿意参与KPD。确保及时移植并为TC提供更优匹配，以及提供互惠政策以确保匹配受者在KPD移植后同种异体移植物失败时能及时接受再次移植，可能会进一步提高匹配对参与KPD的比例。
