抗56,000道尔顿肌肉源性抗原的单克隆抗体对神经肌肉接头处终末轴突发芽的抑制作用
Suppression of terminal axonal sprouting at the neuromuscular junction by monoclonal antibodies against a muscle-derived antigen of 56,000 daltons.
作者信息
Gurney M E, Apatoff B R, Heinrich S P
出版信息
J Cell Biol. 1986 Jun;102(6):2264-72. doi: 10.1083/jcb.102.6.2264.
Abstract
After the partial denervation or paralysis of a muscle, the remaining motor axon terminals may sprout fine, neuritic processes (terminal sprouts) which escape the endplate region of the neuromuscular junction. We previously identified a muscle-derived, protein antigen of 56,000 daltons (56 kD) which plays a necessary role in terminal sprouting. A panel of monoclonal antibodies have been produced against the 56-kD antigen, some of which also partially suppress motor axon terminal sprouting. These monoclonal antibodies define at least two different epitopes upon the surface of the antigen, one of which is necessary for it to effect its biological role in vivo.
摘要
肌肉发生部分去神经支配或麻痹后，剩余的运动轴突终末可能会长出纤细的神经突样突起（终末芽），这些突起会避开神经肌肉接头的终板区域。我们之前鉴定出一种分子量为56,000道尔顿（56 kD）的肌肉源性蛋白质抗原，它在终末芽形成过程中发挥着必要作用。现已制备出一组针对该56-kD抗原的单克隆抗体，其中一些抗体也能部分抑制运动轴突终末的芽生。这些单克隆抗体确定了抗原表面至少两个不同的表位，其中一个表位是其在体内发挥生物学作用所必需的。
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Suppression of terminal axonal sprouting at the neuromuscular junction by monoclonal antibodies against a muscle-derived antigen of 56,000 daltons.抗56,000道尔顿肌肉源性抗原的单克隆抗体对神经肌肉接头处终末轴突发芽的抑制作用
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本文引用的文献
1
DESTRUCTION OF THE SYMPATHETIC GANGLIA IN MAMMALS BY AN ANTISERUM TO A NERVE-GROWTH PROTEIN.用抗神经生长蛋白抗血清破坏哺乳动物的交感神经节
Proc Natl Acad Sci U S A. 1960 Mar;46(3):384-91. doi: 10.1073/pnas.46.3.384.
2
Regression versus peripheral control of differentiation in motor hypoplasia.运动发育不全中分化的回归与外周控制
Am J Anat. 1958 May;102(3):365-409. doi: 10.1002/aja.1001020303.
3
Collateral regeneration in partially denervated muscles.部分失神经支配肌肉中的侧支再生。
Neurology. 1958 Mar;8(3):175-80. doi: 10.1212/wnl.8.3.175.
4
Collateral nerve regeneration.侧支神经再生
Q Rev Biol. 1953 Sep;28(3):260-76. doi: 10.1086/399699.
5
Nodal and terminal sprouting from motor nerves in fast and slow muscles of the mouse.小鼠快肌和慢肌中运动神经的结旁和终末分支。
J Physiol. 1980 Sep;306:493-510. doi: 10.1113/jphysiol.1980.sp013410.
6
Sprouting of active nerve terminals in partially inactive muscles of the rat.大鼠部分失活肌肉中活性神经末梢的发芽
J Physiol. 1980 Jun;303:281-97. doi: 10.1113/jphysiol.1980.sp013285.
7
Identification of embryonic motoneurons in vitro: their survival is dependent on skeletal muscle.体外胚胎运动神经元的鉴定：它们的存活依赖于骨骼肌。
Brain Res. 1980 May 26;190(2):537-42. doi: 10.1016/0006-8993(80)90295-4.
8
The influence of muscle-conditioned medium on cholinergic maturation in spinal cord cell cultures.肌肉条件培养基对脊髓细胞培养中胆碱能成熟的影响。
Brain Res. 1980 Mar 31;186(2):474-9. doi: 10.1016/0006-8993(80)90994-4.
9
Conditioned medium enhances neuritic outgrowth from rat spinal cord explants.条件培养基可促进大鼠脊髓外植体的神经突生长。
Dev Biol. 1980 Jan;74(1):184-95. doi: 10.1016/0012-1606(80)90060-3.
10
The sequential development of nodal sprouts in mouse muscles in response to nerve degeneration.小鼠肌肉中结节状芽体响应神经变性的顺序性发育。
J Neurocytol. 1981 Aug;10(4):537-56. doi: 10.1007/BF01262589.
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