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本文引用的文献

1
Successful intralipid-emulsion treatment of local anesthetic systemic toxicity following ultrasound-guided brachial plexus block: case report.超声引导下臂丛神经阻滞局部麻醉药全身毒性反应的成功脂肪乳剂治疗:病例报告
Int Med Case Rep J. 2019 Jun 28;12:193-197. doi: 10.2147/IMCRJ.S207317. eCollection 2019.
2
Evidence-based recommendations on the use of intravenous lipid emulsion therapy in poisoning.关于中毒时使用静脉脂质乳剂疗法的循证推荐意见。
Clin Toxicol (Phila). 2016 Dec;54(10):899-923. doi: 10.1080/15563650.2016.1214275. Epub 2016 Sep 8.
3
Intralipid Emulsion Rescue Therapy: Emerging Therapeutic Indications in Medical Practice.脂肪乳剂挽救疗法:医学实践中新兴的治疗适应证
J La State Med Soc. 2016 May-Jun;168(3):101-3. Epub 2016 Jun 15.
4
Systematic review of clinical adverse events reported after acute intravenous lipid emulsion administration.急性静脉输注脂质乳剂后报告的临床不良事件的系统评价。
Clin Toxicol (Phila). 2016 Jun;54(5):365-404. doi: 10.3109/15563650.2016.1151528. Epub 2016 Apr 1.
5
Treatment of cocaine cardiovascular toxicity: a systematic review.可卡因心血管毒性的治疗:一项系统评价。
Clin Toxicol (Phila). 2016 Jun;54(5):345-64. doi: 10.3109/15563650.2016.1142090. Epub 2016 Feb 26.
6
Systematic review of the effect of intravenous lipid emulsion therapy for local anesthetic toxicity.静脉注射脂质乳剂治疗局部麻醉药中毒效果的系统评价
Clin Toxicol (Phila). 2016 Mar;54(3):167-93. doi: 10.3109/15563650.2015.1121270. Epub 2016 Feb 6.
7
Systematic review of the effect of intravenous lipid emulsion therapy for non-local anesthetics toxicity.静脉注射脂质乳剂治疗非局部麻醉药毒性效果的系统评价
Clin Toxicol (Phila). 2016 Mar;54(3):194-221. doi: 10.3109/15563650.2015.1126286. Epub 2016 Feb 6.
8
Cardiac depression induced by cocaine or cocaethylene is alleviated by lipid emulsion more effectively than by sulfobutylether-β-cyclodextrin.与磺丁基醚-β-环糊精相比,脂质乳剂能更有效地缓解由可卡因或可口卡因引起的心脏抑制。
Acad Emerg Med. 2015 May;22(5):508-17. doi: 10.1111/acem.12657. Epub 2015 Apr 23.
9
Poisoning with illicit substances: toxicology for the anaesthetist.非法物质中毒:麻醉医师的毒理学。
Anaesthesia. 2013 Jan;68 Suppl 1:117-24. doi: 10.1111/anae.12053.
10
Usefulness of intravenous lipid emulsion for cardiac toxicity from cocaine overdose.静脉注射脂肪乳剂治疗可卡因过量引起的心脏毒性的效果。
Am J Cardiol. 2013 Feb 1;111(3):445-7. doi: 10.1016/j.amjcard.2012.10.022. Epub 2012 Nov 24.

静脉注射脂质乳剂治疗围手术期可卡因中毒

Intravenous Lipid Emulsion for the Treatment of Perioperative Cocaine Intoxication.

作者信息

Saasouh Wael, Nikam Anuja, Hachwa Bachar

机构信息

Anesthesiology, Detroit Medical Center, NorthStar Anesthesia, Detroit, USA.

Medicine, Michigan State University, Detroit, USA.

出版信息

Cureus. 2021 Oct 30;13(10):e19146. doi: 10.7759/cureus.19146. eCollection 2021 Oct.

DOI:10.7759/cureus.19146
PMID:34868781
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8629685/
Abstract

Symptomatic cocaine intoxication in the preoperative period is a potentially life-threatening condition, especially before emergent surgery. The anesthesiologist is faced with a dilemma where the patient is deemed unsafe for induction of general anesthesia but also in need of immediate surgical intervention. Cocaine is a local anesthetic and, as such, has been proposed to respond to lipid emulsion treatment as other local anesthetics would. We present a case supporting this statement and review the relevant published literature on the topic.

摘要

术前出现有症状的可卡因中毒是一种潜在的危及生命的情况,尤其是在急诊手术前。麻醉医生面临两难境地,即患者被认为进行全身麻醉诱导不安全,但又需要立即进行手术干预。可卡因是一种局部麻醉剂,因此有人提出它会像其他局部麻醉剂一样对脂质乳剂治疗产生反应。我们报告一例支持这一观点的病例,并回顾该主题的相关已发表文献。