Muraguchi A, Nishimoto H, Kawamura N, Hori A, Kishimoto T
J Immunol. 1986 Jul 1;137(1):179-86.
This paper demonstrates that B cell lines, as well as normal activated B cells generate and respond to B cell-specific growth factor(s) (BCGF). BCGF derived from B cells (B-BCGF) appears to be distinct from interleukin 1, interleukin 2 (IL 2), B cell stimulatory factor, BCGF-II, interferon-gamma, or transforming growth factor. It acts on activated B cells, but not on resting G0 phase B cells to induce proliferation. B cell lines, immortalized by Epstein-Barr virus, constitutively secrete 10-fold higher level of B-BCGF compared with normal activated B cells, suggesting that an activated autocrine loop might be operating in immortalized B cells. On the basis of our observations, we postulate that B cell clonal expansion may occur, at least in part, through a B-BCGF-dependent autocrine pathway similar to IL 2 effect on T cells.
本文证明，B细胞系以及正常活化的B细胞可产生并对B细胞特异性生长因子（BCGF）作出反应。源自B细胞的BCGF（B-BCGF）似乎不同于白细胞介素1、白细胞介素2（IL-2）、B细胞刺激因子、BCGF-II、干扰素-γ或转化生长因子。它作用于活化的B细胞，而不作用于静止的G0期B细胞以诱导增殖。由爱泼斯坦-巴尔病毒永生化的B细胞系分泌的B-BCGF水平比正常活化的B细胞高10倍，这表明在永生化的B细胞中可能存在活化的自分泌环。基于我们的观察，我们推测B细胞克隆扩增可能至少部分地通过类似于IL-2对T细胞作用的B-BCGF依赖性自分泌途径发生。
