Pan Luyao, Li Bingxin, Chen Jiahua, Zhang Haofeng, Wang Xi, Shou Jiahui, Yang Dejun, Yan Xiaojian
Department of Gynecology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
School of Biomedical Engineering, School of Ophthalmology and Optometry and Eye Hospital, Wenzhou Medical University, Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, China.
Front Chem. 2021 Nov 17;9:798727. doi: 10.3389/fchem.2021.798727. eCollection 2021.
Persistent human papillomavirus (HPV) infection will eventually lead to clinical problems, varying from verrucous lesions to malignancies like cervical cancer, oral cancer, anus cancer, and so on. To address the aforementioned problems, nanotechnology-based strategies have been applied to detect the virus, prevent the interaction between virus and mammalian cells, and treat the virus-infected cells, due mainly to the unique physicochemical properties of nanoparticles. In this regard, many nanotechnology-based chemotherapies, gene therapy, vaccination, or combination therapy have been developed. In this Minireview, we outline the pathogenesis of HPV infection and the recent advances in nanotechnology-based weapons that can be applied in combating HPV-associated diseases.
持续性人乳头瘤病毒（HPV）感染最终会导致临床问题，范围从疣状病变到诸如宫颈癌、口腔癌、肛门癌等恶性肿瘤。为了解决上述问题，基于纳米技术的策略已被应用于检测病毒、防止病毒与哺乳动物细胞之间的相互作用以及治疗病毒感染的细胞，这主要归因于纳米颗粒独特的物理化学性质。在这方面，已经开发了许多基于纳米技术的化疗、基因治疗、疫苗接种或联合治疗方法。在本综述中，我们概述了HPV感染的发病机制以及可用于对抗HPV相关疾病的基于纳米技术的手段的最新进展。
