Chen Jiahui, Tang Yating, Jing Qinghe, Lu Yi, Jiang Yongxiang
Department of Ophthalmology and Vision Science, Eye Ear Nose and Throat Hospital of Fudan University, Shanghai, China.
National Health Commission (NHC) Key Laboratory of Myopia (Fudan University), Laboratory of Myopia, Chinese Academy of Medical Sciences, Shanghai, China.
Front Med (Lausanne). 2021 Nov 19;8:736686. doi: 10.3389/fmed.2021.736686. eCollection 2021.
To analyze the anterior, posterior, and total corneal spherical aberrations (ASA, PSA, and TSA) in patients with Chinese bilateral ectopia lentis (EL). A cross-sectional study was conducted to evaluate corneal spherical aberration (CSA) using a Pentacam system at the 6-mm optical zone. Axial length, keratometry, astigmatism, and corneal asphericity were also determined. This study included 247 patients (420 eyes) with a mean age of 18.1 years. The values of ASA, PSA, and TSA were 0.136 ± 0.100 μm, -0.118 ± 0.030 μm, and 0.095 ± 0.095 μm, respectively. In the EL patients with Marfan syndrome (MFS), ASA and TSA were significantly lower than in the non-MFS patients (0.126 ± 0.094 μm vs. 0.155 ± 0.107 μm, = 0.004 for ASA; 0.085 ± 0.091 μm vs. 0.114 ± 0.099 μm, = 0.003 for TSA), whereas PSA was not significantly different ( = 0.061). The values of ASA and TSA were significantly higher in the patients with EL aged ≥ 40 years old than in younger patients, whereas ASA and PSA were lower in patients aged <10 years old than in older patients (all < 0.05). In the multiple linear regression analysis, age, keratometry, astigmatism, anterior asphericity, higher-order aberration (HOA), and lower-order aberration (LOA) were positively or negatively correlated with TSA in the patients with EL ( = 0.681, < 0.001). Corneal spherical aberration was low in the patients with EL especially for MFS and tended to increase with aging. Preoperatively, individual measurement of CSA was necessary for bilateral EL patients with MFS.
分析中国双侧晶状体异位（EL）患者的角膜前表面、后表面及总球面像差（ASA、PSA和TSA）。采用Pentacam系统在6mm光学区进行横断面研究，评估角膜球面像差（CSA）。同时测定眼轴长度、角膜曲率、散光和角膜非球面性。本研究纳入247例患者（420只眼），平均年龄18.1岁。ASA、PSA和TSA值分别为0.136±0.100μm、-0.118±0.030μm和0.095±0.095μm。在患有马凡综合征（MFS）的EL患者中，ASA和TSA显著低于非MFS患者（ASA：0.126±0.094μm对0.155±0.107μm，P = 0.004；TSA：0.085±0.091μm对0.114±0.099μm，P = 0.003），而PSA无显著差异（P = 0.061）。年龄≥40岁的EL患者的ASA和TSA值显著高于年轻患者，而年龄<10岁的患者的ASA和PSA低于年长患者（均P<0.05）。在多元线性回归分析中，年龄、角膜曲率、散光、前表面非球面性、高阶像差（HOA）和低阶像差（LOA）与EL患者的TSA呈正相关或负相关（R² = 0.681，P<0.001）。EL患者尤其是MFS患者的角膜球面像差较低，且有随年龄增长而增加的趋势。术前，对于患有MFS的双侧EL患者，有必要单独测量CSA。
