Brodack J W, Kilbourn M R, Welch M J, Katzenellenbogen J A
J Nucl Med. 1986 May;27(5):714-21.
A commercially available robot system, the Zymark Zymate Laboratory Automation System, has been utilized for the preparation of a positron-emitting radiopharmaceutical, 16 alpha-[18F] fluoroestradiol-17 beta. This radiopharmaceutical is prepared in a three-step synthesis (preparation of [18F]-tetrabutylammonium fluoride, SN2 displacement of a triflate, and ketone reduction) and is purified by high performance liquid chromatography (HPLC). All steps in the synthesis and HPLC purification are controlled by the robot system with no manual intervention. This represents a new approach to the complete automation of radiopharmaceutical production.
一种市售的机器人系统——Zymark Zymate实验室自动化系统，已被用于制备正电子发射放射性药物16α-[18F]氟雌二醇-17β。这种放射性药物通过三步合成法制备（[18F] - 四丁基氟化铵的制备、三氟甲磺酸酯的SN2取代以及酮的还原），并通过高效液相色谱法（HPLC）进行纯化。合成和HPLC纯化的所有步骤均由机器人系统控制，无需人工干预。这代表了一种实现放射性药物生产完全自动化的新方法。
