Bustos Nicolas I, Sotomayor Camilo G, Pol Robert A, Navis Gerjan J, Bakker Stephan J L
Faculty of Medicine, Institute of Biomedical Sciences, University of Chile, Santiago, Chile.
Division of Nephrology, Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.
Front Cardiovasc Med. 2021 Nov 16;8:751036. doi: 10.3389/fcvm.2021.751036. eCollection 2021.
Kidney transplantation is the preferred treatment for end-stage kidney disease. It is, however, not devoid of complications. Delayed graft function related to ischemia-reperfusion injury (IRI), calcineurin inhibitor (CNI) nephrotoxicity, diabetes, and a particularly high-rate cardiovascular disease (CVD) risk, represent important complications following kidney transplantation. Oxidative stress and chronic low-grade inflammation are mechanisms of disease incompletely abrogated in stable kidney transplant recipient (KTR), contributing to the occurrence of these complications. Polyphenols, bioactive compounds with recognized antioxidant and anti-inflammatory properties have been strongly associated with prevention of CVD in the general population and have been shown to decrease IRI and antagonize CNI nephrotoxicity in animal experimental models, therefore they may have a role in prevention of complications in KTR. This narrative review aims to summarize and discuss current evidence on different polyphenols for prevention of complications, particularly prevention of CVD in KTR, pointing toward the need of further studies with potential clinical impact.
肾移植是终末期肾病的首选治疗方法。然而，它并非没有并发症。与缺血再灌注损伤（IRI）、钙调神经磷酸酶抑制剂（CNI）肾毒性、糖尿病相关的移植肾功能延迟，以及特别高的心血管疾病（CVD）风险，是肾移植后的重要并发症。氧化应激和慢性低度炎症是稳定的肾移植受者（KTR）中未完全消除的疾病机制，促成了这些并发症的发生。多酚是具有公认抗氧化和抗炎特性的生物活性化合物，在普通人群中与预防CVD密切相关，并且在动物实验模型中已显示可减少IRI并拮抗CNI肾毒性，因此它们可能在预防KTR并发症中发挥作用。本叙述性综述旨在总结和讨论关于不同多酚预防并发症，特别是预防KTR中CVD的现有证据，指出需要进行具有潜在临床影响的进一步研究。
