Asaoka Ryo, Oishi Akio, Fujino Yuri, Murata Hiroshi, Azuma Keiko, Miyata Manabu, Obata Ryo, Inoue Tatsuya
Department of Ophthalmology, The University of Tokyo Hospital, Bunkyo-ku, Tokyo, Japan
Nanovision Research Division, Research Institute of Electronics, Shizuoka University, Shizuoka, Japan.
BMJ Open Ophthalmol. 2021 Nov 18;6(1):e000900. doi: 10.1136/bmjophth-2021-000900. eCollection 2021.
To evaluate the minimum number of visual fields (VFs) required to precisely predict future VFs in eyes with retinitis pigmentosa (RP).
A series of 12 VFs (Humphrey Field Analyzer 10-2 test (8.9 years in average) were analysed from 102 eyes of 52 patients with RP. The absolute error to predict the 12th VF using the prior 11 VFs was calculated in a pointwise manner, using the linear regression, and the 95% CI range was determined. Then, using 3-10 initial VFs, next VFs (4th to 11th VFs, respectively) were also predicted. The minimum number of VFs required for the mean absolute prediction error to reach the 95% CI was identified. Similar analyses were iterated for the second and third next VF predictions. Similar analyses were conducted using mean deviation (MD).
In the pointwise analysis, the minimum number of VFs required to reach the 95% CI for the 12th VF was five (first and second next VF predictions) and six (third next VF prediction). For the MD analysis, three (first and second next VF predictions) and four (third next VF prediction) VFs were required to reach 95% CI for the 12th VF.
The minimum number of VFs required to obtain accurate predictions of the future VF was five or six in the pointwise analysis and three or four in the analysis with MD.
评估在视网膜色素变性（RP）患者眼中精确预测未来视野（VF）所需的最少视野检查次数。
对52例RP患者的102只眼睛进行了一系列12次视野检查（Humphrey视野分析仪10 - 2检测，平均8.9年）。使用线性回归逐点计算用前11次视野检查预测第12次视野检查的绝对误差，并确定95%置信区间（CI）范围。然后，使用3 - 10次初始视野检查，分别预测接下来的视野检查（第4至11次视野检查）。确定平均绝对预测误差达到95% CI所需的最少视野检查次数。对接下来的第二次和第三次视野检查预测进行类似分析。使用平均偏差（MD）进行类似分析。
在逐点分析中，预测第12次视野检查达到95% CI所需的最少视野检查次数，对于接下来的第一次和第二次视野检查预测为5次，对于第三次视野检查预测为6次。对于MD分析，预测第12次视野检查达到95% CI，对于接下来的第一次和第二次视野检查预测需要3次，对于第三次视野检查预测需要4次。
在逐点分析中，获得未来视野准确预测所需的最少视野检查次数为5或6次，在MD分析中为3或4次。
