Department of Ophthalmology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Department of Biostatistics, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Sci Rep. 2017 Nov 27;7(1):16383. doi: 10.1038/s41598-017-16640-7.
The aim of this study is to determine the progress of the visual field defects obtained by the Humphrey Field Analyzer 10-2 program (HFA 10-2) in patients with retinitis pigmentosa (RP). The medical records of 45 eyes of 45 RP patients who had at least 3 visual field tests were reviewed. Linear mixed models were used to follow the changes of the mean deviation and the average sensitivity of 4, 12, and 20 points in three concentric squares, designated as S4, S12, and S20. The median follow-up time was 3.86 years [range: 1.93 to 9.86, IQR (Interquartile range): 3.01 to 4.93]. The median number of the visual field tests was 3 (range: 3 to 15, IQR: 3 to 4). The mean change of the MD was -0.46 dB/year (-5.80%/year). When the patients were grouped by the average initial MD, the less advanced group had slower progressions than the more advanced group in S4, S12, and S20. These results should be useful in understanding the pathological changes of RP in the central visual field.
本研究旨在探讨色素性视网膜炎（RP）患者通过 Humphrey 视野分析仪 10-2 程序（HFA 10-2）获得的视野缺损进展情况。我们回顾了 45 例 RP 患者的 45 只眼至少进行了 3 次视野检查的病历资料。采用线性混合模型对 3 个同心正方形（S4、S12 和 S20）中 4、12 和 20 点平均偏差和平均敏感度的变化进行随访。中位随访时间为 3.86 年[范围：1.93 至 9.86，IQR（四分位间距）：3.01 至 4.93]。中位视野检查次数为 3 次（范围：3 至 15，IQR：3 至 4）。平均 MD 变化为-0.46dB/年（-5.80%/年）。当根据平均初始 MD 将患者分组时，S4、S12 和 S20 中进展较慢的组比进展较快的组进展更慢。这些结果有助于了解中央视野中 RP 的病理变化。
