Nakayama Masao, Akasaka Hiroaki, Miyazaki Eiichi, Goto Yoshihiro, Oki Yuya, Kawate Yosuke, Morita Kenta, Sasaki Ryohei
Division of Radiation Therapy, Kita-Harima Medical Center, 926-250 Ichibacho, Ono, Hyogo 675-1392, Japan.
Division of Radiation Oncology, Kobe University Graduate School of Medicine, 7-5-2 Kusunokicho, Chuou-ku, Kobe, Hyogo 650-0017, Japan.
Phys Imaging Radiat Oncol. 2021 Nov 23;20:94-97. doi: 10.1016/j.phro.2021.11.003. eCollection 2021 Oct.
Metal-based nanoparticles (NPs) have been extensively studied for dose enhancement applications in radiation therapy. This study investigated the utility of such NPs for image-guided radiation therapy (IGRT). Phantom images of gold NPs (AuNPs) and titanium peroxide NPs (TiOxNPs) with different concentrations were acquired using IGRT modalities, including cone-beam computed tomography (CBCT). AuNPs induced strong contrast enhancement in kV energy CBCT images, whereas TiOxNPs at high concentrations showed weak but detectable changes. The results indicated that these NPs can be used to enhance IGRT images as well as dose enhancement for treatment purposes.
基于金属的纳米颗粒（NPs）已被广泛研究用于放射治疗中的剂量增强应用。本研究调查了此类纳米颗粒在图像引导放射治疗（IGRT）中的效用。使用包括锥形束计算机断层扫描（CBCT）在内的IGRT模态获取了不同浓度的金纳米颗粒（AuNPs）和过氧化钛纳米颗粒（TiOxNPs）的体模图像。AuNPs在千伏能量CBCT图像中引起强烈的对比度增强，而高浓度的TiOxNPs显示出微弱但可检测到的变化。结果表明，这些纳米颗粒可用于增强IGRT图像以及用于治疗目的的剂量增强。
