• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

氧化铈纳米颗粒对大鼠非酒精性脂肪性肝病（NAFLD）及四氯化碳诱导的肝损伤的保护作用：肠道与肝脏的研究

Protective effects of cerium oxide nanoparticles in non-alcoholic fatty liver disease (NAFLD) and carbon tetrachloride-induced liver damage in rats: Study on intestine and liver.

作者信息

Abbasi Ebrahim, Vafaei Seyed Alireza, Naseri Nima, Darini Ali, Azandaryani Masoumeh Taheri, Ara Farhad Kian, Mirzaei Fatemeh

机构信息

Department of Biochemistry, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.

Department of Biology, Islamic Azad University, Sanandaj Branch, Sanandaj, Iran.

出版信息

Metabol Open. 2021 Nov 18;12:100151. doi: 10.1016/j.metop.2021.100151. eCollection 2021 Dec.

DOI:10.1016/j.metop.2021.100151
PMID:34870139
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8626579/
Abstract

BACKGROUND AND AIMS

Nanoparticles could represent a therapeutic approach for the treatment of various diseases. It has been reported that cerium oxide nanoparticles (CeO NPs) have potential useful effects. Therefore, we aimed to examine the protective effects of the CeO NPs in two models of liver injury, non-alcoholic fatty liver disease (NAFLD) and carbon tetrachloride (CCl)-induced liver fibrosis, in rats.

METHODS

In this experimental study, male rats were randomly divided into different experimental groups including: Experiment 1; group1: healthy rats received normal saline, 2: CCl group, 3: CCl + nanoparticle. Experiment 2; group1: healthy rats received chow diet, 2: NAFLD group, 3: NAFLD + nanoparticle. The oxidative stress markers were determined in the liver and intestine. Tumor necrosis factor-α (TNF-α) levels were measured by ELISA. Histopathological changes of liver and intestine were evaluated by light microspore.

RESULTS

Total antioxidant capacity (TAC) and glutathione (GSH) levels significantly decreased, while malondialdehyde (MDA) and total oxidant status (TOS) were significantly increased in the liver, and intestine of the NAFLD and CCl group compared with control rats. However, the use of nanoparticles significantly normalized these markers. The levels of the TNF-α were significantly reduced in the nanoparticle group as compared with NAFLD model and CCl-treated rats. CeO NPs also normalized the liver and intestinal histological changes.

CONCLUSIONS

Our finding revealed that CeO NPs has potential protective effects by increasing antioxidant activity, and reducing inflammation.

摘要

背景与目的

纳米颗粒可能是治疗多种疾病的一种方法。据报道，氧化铈纳米颗粒（CeO NPs）具有潜在的有益作用。因此，我们旨在研究CeO NPs在大鼠非酒精性脂肪性肝病（NAFLD）和四氯化碳（CCl）诱导的肝纤维化这两种肝损伤模型中的保护作用。

方法

在本实验研究中，雄性大鼠被随机分为不同的实验组，包括：实验1；第1组：健康大鼠接受生理盐水，第2组：CCl组，第3组：CCl +纳米颗粒组。实验2；第1组：健康大鼠接受普通饮食，第2组：NAFLD组，第3组：NAFLD +纳米颗粒组。测定肝脏和肠道中的氧化应激标志物。通过酶联免疫吸附测定法（ELISA）测量肿瘤坏死因子-α（TNF-α）水平。通过光学显微镜评估肝脏和肠道的组织病理学变化。

结果

与对照大鼠相比，NAFLD组和CCl组大鼠的肝脏和肠道中总抗氧化能力（TAC）和谷胱甘肽（GSH）水平显著降低，而丙二醛（MDA）和总氧化剂状态（TOS）显著升高。然而，使用纳米颗粒可使这些标志物显著恢复正常。与NAFLD模型组和CCl处理组大鼠相比，纳米颗粒组中TNF-α水平显著降低。CeO NPs还使肝脏和肠道的组织学变化恢复正常。

结论

我们的研究结果表明，CeO NPs通过提高抗氧化活性和减轻炎症具有潜在的保护作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2da6/8626579/dbf715c66d51/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2da6/8626579/922574cb53ed/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2da6/8626579/9f6e8127f161/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2da6/8626579/d7fb2b83c41a/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2da6/8626579/0ea232a4f939/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2da6/8626579/3d92d30d6cb9/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2da6/8626579/2e482158acbc/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2da6/8626579/6d2eb1958222/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2da6/8626579/dbf715c66d51/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2da6/8626579/922574cb53ed/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2da6/8626579/9f6e8127f161/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2da6/8626579/d7fb2b83c41a/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2da6/8626579/0ea232a4f939/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2da6/8626579/3d92d30d6cb9/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2da6/8626579/2e482158acbc/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2da6/8626579/6d2eb1958222/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2da6/8626579/dbf715c66d51/gr8.jpg

相似文献

1
Protective effects of cerium oxide nanoparticles in non-alcoholic fatty liver disease (NAFLD) and carbon tetrachloride-induced liver damage in rats: Study on intestine and liver.氧化铈纳米颗粒对大鼠非酒精性脂肪性肝病（NAFLD）及四氯化碳诱导的肝损伤的保护作用：肠道与肝脏的研究
Metabol Open. 2021 Nov 18;12:100151. doi: 10.1016/j.metop.2021.100151. eCollection 2021 Dec.
2
Multi-organ Toxicity Attenuation by Cerium Oxide and Yttrium Oxide Nanoparticles: Comparing the Beneficial Effects on Tissues Oxidative Damage Induced by Sub-acute Exposure to Diazinon.氧化铈和氧化钇纳米粒子对多器官毒性的衰减作用：亚急性暴露于二嗪农诱导的组织氧化损伤的有益效果比较。
Pharm Nanotechnol. 2020;8(3):225-238. doi: 10.2174/2211738508666200808135226.
3
Aortic Oxidative Stress, Inflammation and DNA Damage Following Pulmonary Exposure to Cerium Oxide Nanoparticles in a Rat Model of Vascular Injury.大鼠血管损伤模型中肺暴露于氧化铈纳米颗粒后主动脉氧化应激、炎症和 DNA 损伤。
Biomolecules. 2019 Aug 17;9(8):376. doi: 10.3390/biom9080376.
4
Is human umbilical cord mesenchymal stem cell-derived conditioned medium effective against oxidative and inflammatory status in CCl-induced acute liver injury?人脐带间充质干细胞条件培养液对 CCl4 诱导的急性肝损伤的氧化和炎症状态是否有效？
Life Sci. 2022 Sep 15;305:120730. doi: 10.1016/j.lfs.2022.120730. Epub 2022 Jun 23.
5
The protective effect of chrysin against carbon tetrachloride-induced kidney and liver tissue damage in rats.白杨素对四氯化碳致大鼠肝肾组织损伤的保护作用。
Int J Vitam Nutr Res. 2021 Sep;91(5-6):427-438. doi: 10.1024/0300-9831/a000653. Epub 2020 Apr 30.
6
Cerium oxide nanoparticles modulate liver X receptor and short heterodimer partner, and attenuate liver steatosis and steatohepatitis in a rat model of postmenopausal obesity.氧化铈纳米颗粒调节肝 X 受体和短异二聚体伴侣，减轻绝经后肥胖大鼠模型的肝脂肪变性和脂肪性肝炎。
Gen Physiol Biophys. 2022 Sep;41(5):431-446. doi: 10.4149/gpb_202235.
7
Jiang-Zhi granules decrease sensitivity to low-dose CCl induced liver injury in NAFLD rats through reducing endoplasmic reticulum stress.降脂颗粒通过降低内质网应激降低 NAFLD 大鼠对低剂量 CCl 诱导的肝损伤的敏感性。
BMC Complement Altern Med. 2019 Aug 22;19(1):228. doi: 10.1186/s12906-019-2641-2.
8
N-Acetyl cysteine amide and cerium oxide nanoparticles as a drug delivery for ischemic stroke treatment: Inflammation and oxidative stress crosstalk.N-乙酰半胱氨酸酰胺和氧化铈纳米颗粒作为治疗缺血性中风的药物递送系统：炎症与氧化应激的相互作用。
J Trace Elem Med Biol. 2023 Dec;80:127300. doi: 10.1016/j.jtemb.2023.127300. Epub 2023 Sep 18.
9
The involvement of Nrf2 in the protective effects of diallyl disulfide on carbon tetrachloride-induced hepatic oxidative damage and inflammatory response in rats.二烯丙基二硫对四氯化碳诱导的大鼠肝氧化损伤和炎症反应的保护作用与 Nrf2 的关系。
Food Chem Toxicol. 2014 Jan;63:174-85. doi: 10.1016/j.fct.2013.11.006. Epub 2013 Nov 15.
10
Astaxanthin Ameliorates Hepatic Damage and Oxidative Stress in Carbon Tetrachloride-administered Rats.虾青素改善四氯化碳诱导的大鼠肝损伤和氧化应激
Pharmacognosy Res. 2017 Dec;9(Suppl 1):S84-S91. doi: 10.4103/pr.pr_26_17.

引用本文的文献

1
Silver Nanoparticles Synthesized from Exhibit Gut Tight Junction Restoration and Hepatoprotective Activity via Regulation of the Inflammatory Pathway.从……合成的银纳米颗粒通过调节炎症途径展现肠道紧密连接修复和肝脏保护活性。 （注：原文“from”后内容缺失）
Pharmaceutics. 2025 Jul 9;17(7):895. doi: 10.3390/pharmaceutics17070895.
2
Effects of cerium oxide nanoparticle on liver oxidative stress and morphological changes in opium withdrawal rats.氧化铈纳米颗粒对戒断鸦片大鼠肝脏氧化应激及形态学变化的影响
Toxicol Rep. 2025 Apr 9;14:102025. doi: 10.1016/j.toxrep.2025.102025. eCollection 2025 Jun.
3
Therapeutic Nanomaterials in NAFLD: Current Advances and Potential Applications in Patients with Concurrent HBV Infection.

本文引用的文献

1
Economic sanctions and Iran's capacity to respond to COVID-19.经济制裁与伊朗应对新冠疫情的能力
Lancet Public Health. 2020 May;5(5):e254. doi: 10.1016/S2468-2667(20)30083-9. Epub 2020 Apr 6.
2
Role of oxidative stress in the pathogenesis of nonalcoholic fatty liver disease.氧化应激在非酒精性脂肪性肝病发病机制中的作用。
Free Radic Biol Med. 2020 May 20;152:116-141. doi: 10.1016/j.freeradbiomed.2020.02.025. Epub 2020 Mar 8.
3
Effect of High-Fat Diets on Oxidative Stress, Cellular Inflammatory Response and Cognitive Function.
非酒精性脂肪性肝病中的治疗性纳米材料：在合并乙型肝炎病毒感染患者中的当前进展及潜在应用
Int J Nanomedicine. 2025 Mar 25;20:3803-3823. doi: 10.2147/IJN.S510271. eCollection 2025.
4
Potential Applications of Rare Earth Metal Nanoparticles in Biomedicine.稀土金属纳米粒子在生物医学中的潜在应用
Pharmaceuticals (Basel). 2025 Jan 24;18(2):154. doi: 10.3390/ph18020154.
5
Radioprotective Potency of Nanoceria.纳米氧化铈的辐射防护功效。
Curr Radiopharm. 2024;17(2):138-147. doi: 10.2174/0118744710267281231104170435.
6
Effectiveness of Cerium Oxide Nanoparticles in Non-Alcoholic Fatty Liver Disease Evolution Using In Vivo and In Vitro Studies: A Systematic Review.体内和体外研究中氧化铈纳米粒子在非酒精性脂肪肝病进展中的有效性：系统评价。
Int J Mol Sci. 2023 Oct 29;24(21):15728. doi: 10.3390/ijms242115728.
7
The Impressive Anti-Inflammatory Activity of Cerium Oxide Nanoparticles: More than Redox?氧化铈纳米颗粒令人印象深刻的抗炎活性：不止于氧化还原？
Nanomaterials (Basel). 2023 Oct 21;13(20):2803. doi: 10.3390/nano13202803.
8
Stress mechanism involved in the progression of alcoholic liver disease and the therapeutic efficacy of nanoparticles.酒精性肝病进展中涉及的应激机制和纳米粒子的治疗效果。
Front Immunol. 2023 Sep 29;14:1205821. doi: 10.3389/fimmu.2023.1205821. eCollection 2023.
9
Editorial: Special issue: Non-alcoholic fatty liver disease: From molecular basis to therapeutic advances.社论：特刊：非酒精性脂肪性肝病：从分子基础到治疗进展
Metabol Open. 2023 Jan 13;17:100229. doi: 10.1016/j.metop.2023.100229. eCollection 2023 Mar.
10
Intranasal Cerium Oxide Nanoparticles Ameliorate Cognitive Function in Rats with Alzheimer's via Anti-Oxidative Pathway.鼻内注射氧化铈纳米颗粒通过抗氧化途径改善阿尔茨海默病大鼠的认知功能。
Pharmaceutics. 2022 Mar 30;14(4):756. doi: 10.3390/pharmaceutics14040756.
高脂肪饮食对氧化应激、细胞炎症反应和认知功能的影响。
Nutrients. 2019 Oct 25;11(11):2579. doi: 10.3390/nu11112579.
4
Cerium oxide nanoparticles improve liver regeneration after acetaminophen-induced liver injury and partial hepatectomy in rats.氧化铈纳米颗粒可改善大鼠乙酰氨基酚诱导的肝损伤和部分肝切除术后的肝再生。
J Nanobiotechnology. 2019 Oct 31;17(1):112. doi: 10.1186/s12951-019-0544-5.
5
Cerium oxide nanoparticles display antilipogenic effect in rats with non-alcoholic fatty liver disease.氧化铈纳米颗粒在非酒精性脂肪肝大鼠中显示出抗脂肪生成作用。
Sci Rep. 2019 Sep 6;9(1):12848. doi: 10.1038/s41598-019-49262-2.
6
Drug-Induced Liver Injury - Types and Phenotypes.药物性肝损伤——类型与表型
N Engl J Med. 2019 Jul 18;381(3):264-273. doi: 10.1056/NEJMra1816149.
7
Cell death in drug-induced liver injury.药物性肝损伤中的细胞死亡
Adv Pharmacol. 2019;85:31-74. doi: 10.1016/bs.apha.2019.01.006. Epub 2019 Feb 20.
8
Negative Effects of a High-Fat Diet on Intestinal Permeability: A Review.高脂肪饮食对肠道通透性的负面影响：综述。
Adv Nutr. 2020 Jan 1;11(1):77-91. doi: 10.1093/advances/nmz061.
9
Functionalized cerium oxide nanoparticles mitigate the oxidative stress and pro-inflammatory activity associated to the portal vein endothelium of cirrhotic rats.功能化氧化铈纳米颗粒减轻了肝硬化大鼠门静脉内皮细胞相关的氧化应激和促炎活性。
PLoS One. 2019 Jun 24;14(6):e0218716. doi: 10.1371/journal.pone.0218716. eCollection 2019.
10
NLRP3 inflammasome, oxidative stress, and apoptosis induced in the intestine and liver of rats treated with titanium dioxide nanoparticles: in vivo and in vitro study.二氧化钛纳米颗粒处理的大鼠肠道和肝脏中 NLRP3 炎性体、氧化应激和细胞凋亡：体内和体外研究。
Int J Nanomedicine. 2019 Mar 15;14:1919-1936. doi: 10.2147/IJN.S192382. eCollection 2019.