Li Guixin, Dai Zheng, Guo Jinghui
Department of Gastroenterology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China.
Research Center for Tissue Engineering and Regenerative Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People's Republic of China.
Int J Nanomedicine. 2025 Mar 25;20:3803-3823. doi: 10.2147/IJN.S510271. eCollection 2025.
Due to the high prevalence of non-alcoholic fatty liver disease (NAFLD) and chronic hepatitis B virus (HBV) infection, a significant proportion of patients suffer from both conditions simultaneously. The management of NAFLD in patients with concurrent HBV infection presents unique challenges, primarily due to the complex interplay between these two diseases. Nanomaterials have gained widespread attention due to their ability to overcome the limitations of conventional therapies. This review provides an overview of the current advances in therapeutic nanomaterials for NAFLD and explores their potential applications for personalized and effective management in patients with concurrent HBV infection. Furthermore, we discuss the challenges and future directions in the development of nanomaterials for the treatment of coexisting liver diseases.
由于非酒精性脂肪性肝病(NAFLD)和慢性乙型肝炎病毒(HBV)感染的高流行率,相当一部分患者同时患有这两种疾病。同时感染HBV的患者中NAFLD的管理面临独特挑战,主要是由于这两种疾病之间复杂的相互作用。纳米材料因其能够克服传统疗法的局限性而受到广泛关注。本综述概述了用于NAFLD的治疗性纳米材料的当前进展,并探讨了它们在同时感染HBV的患者中进行个性化有效管理的潜在应用。此外,我们讨论了用于治疗并存肝病的纳米材料开发中的挑战和未来方向。