Özdemir Hande, Tuna Filiz, Aktoz Meryem, Taştekin Nurettin, Demirbağ Kabayel Derya
Department of Physical Therapy and Rehabilitation, Uzunköprü State Hospital, Edirne, Turkey.
Department of Physical Therapy and Rehabilitation, Trakya University Faculty of Medicine, Edirne, Turkey.
Arch Rheumatol. 2021 Jan 21;36(3):335-340. doi: 10.46497/ArchRheumatol.2021.8192. eCollection 2021 Sep.
The aim of this study was to investigate the frequency of mitral valve prolapse between healthy females with generalized joint hypermobility and healthy controls.
This observational, cross-sectional, controlled study included female individuals with generalized joint hypermobility (n=39, mean age: 20.5±1.1 years; range, 19 to 23 years) and healthy controls (n=42, mean age: 20.6±1.2 years; range, 18 to 23 years) between July 2017 and November 2017. The generalized joint hypermobility consisted of women with a Beighton score of ≥4, while the control group consisted of women with a Beighton score of ≤3. Echocardiography was performed to all participants. Mitral valve prolapse was defined as having single or bileaflet prolapse of at least 2 mm beyond the long-axis annular plane with or without mitral leaflet thickening.
No significant difference was found in the age, height, body weight, and body mass index between the groups (p>0.05). The median Beighton score was 5 in the generalized joint hypermobility group and 2 in the control group. No mitral valve prolapse was detected in those with generalized joint hypermobility, while non-classical mitral valve prolapse was observed in one participant in the control group, indicating no statistically significant difference between the two groups (p>0.05).
Our study results suggest that the frequency of mitral valve prolapse is comparable between the women with generalized joint hypermobility and healthy controls. Based on these results, routine assessment of mitral valve prolapse is not recommended in this population.
本研究旨在调查具有全身关节活动过度的健康女性与健康对照组之间二尖瓣脱垂的发生率。
这项观察性、横断面、对照研究纳入了2017年7月至2017年11月期间具有全身关节活动过度的女性个体（n = 39，平均年龄：20.5±1.1岁；范围19至23岁）和健康对照组（n = 42，平均年龄：20.6±1.2岁；范围18至23岁）。全身关节活动过度包括Beighton评分≥4的女性，而对照组包括Beighton评分≤3的女性。对所有参与者进行了超声心动图检查。二尖瓣脱垂定义为单叶或双叶脱垂至少超出长轴瓣环平面2 mm，伴有或不伴有二尖瓣叶增厚。
两组之间在年龄、身高、体重和体重指数方面未发现显著差异（p>0.05）。全身关节活动过度组的Beighton评分中位数为5，对照组为2。在全身关节活动过度的患者中未检测到二尖瓣脱垂，而在对照组的一名参与者中观察到非典型二尖瓣脱垂，表明两组之间无统计学显著差异（p>0.05）。
我们的研究结果表明，具有全身关节活动过度的女性与健康对照组之间二尖瓣脱垂的发生率相当。基于这些结果，不建议对该人群进行二尖瓣脱垂的常规评估。
