Street D A, Vinokur E T, Waring G O, Pollak S J, Clements S D, Perkins J V
Emory University School of Medicine, Department of Ophthalmology, Atlanta.
Ophthalmology. 1991 Feb;98(2):170-6. doi: 10.1016/s0161-6420(91)32320-0.
The authors enrolled 95 patients with keratoconus and 96 matched controls in a cross-sectional study to determine if mitral valve prolapse and hypermobile joints occur with greater frequency in individuals with keratoconus than in individuals without keratoconus. The hypothesis that keratoconus may not be a distinct eye disease, but a nonspecific sign representing a more generalized systemic disorder, possibly a mild collagen tissue abnormality, was considered. M-mode and two dimensional echocardiography and cardiac auscultation detected no statistically significant difference in the prevalence of mitral valve prolapse in patients with keratoconus compared with controls. Formal, systematic examination of five joints also failed to detect a statistically significant difference in the prevalence of hypermobile joints in keratoconus patients and controls. However, as an ancillary finding, a significantly higher proportion of patients with keratoconus was found to have a history of hay fever than was the case with controls.
作者纳入了95例圆锥角膜患者和96例匹配的对照进行一项横断面研究，以确定二尖瓣脱垂和关节过度活动在圆锥角膜患者中出现的频率是否高于非圆锥角膜患者。研究考虑了这样一种假设，即圆锥角膜可能并非一种独特的眼部疾病，而是一种代表更广泛全身性疾病（可能是轻度胶原组织异常）的非特异性体征。M型和二维超声心动图以及心脏听诊未发现圆锥角膜患者与对照组在二尖瓣脱垂患病率上有统计学显著差异。对五个关节进行的正规、系统检查也未发现圆锥角膜患者与对照组在关节过度活动患病率上有统计学显著差异。然而，作为一项辅助发现，发现圆锥角膜患者中有花粉症病史的比例显著高于对照组。
