Dimaano Kathrina Antheia M, Shah Nensi, AlQassab Osamah, Al-Sulaitti Zainab, Nelakuditi Bhavana, Dandamudi Bindu Jyothi, Khan Safeera
Obstetrics and Gynecology, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA.
Internal Medicine, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA.
Cureus. 2024 Nov 30;16(11):e74866. doi: 10.7759/cureus.74866. eCollection 2024 Nov.
Preterm delivery remains a prominent problem in obstetrics with significant adverse implications for both mothers and the offspring. The incidence of mitral valve prolapse (MVP) in women of childbearing age has raised concerns about pregnancy and pregnancy connotations. The objective of this systematic review and meta-analysis is to help in understanding the plausibility of the association between MVP and preterm birth in women with a history of frequent deliveries. Following the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines, we searched the databases, including PubMed, Embase, Cochrane Library, Web of Science, and Scopus, for studies published in the period 1999 through 2024. Inclusion criteria consisted of studies such as cohort, cross-sectional, and case-control studies related to women diagnosed with MVP out of a total number of 1,029 articles found. Overall, a total of 19 studies were included in this review, with 3 of which were considered for further meta-analysis. It was revealed in the analysis that there was an association between MVP and preterm delivery when the severity of MVP was at Types II and III. The evidence also underscores the importance of both follow-up and preemptive measures among women suffering from MV prolapse for improved maternal and neonatal outcomes. The average Z-value (4.47) and p-value (0.00) for the test for overall effect size indicate the presence of a high correlation between MVP and premature delivery, suggesting satisfactory statistics on the association. The findings do indicate that MVP is a risk factor for preterm delivery (pooled ES = 0.24, 95% CI = 0.14 to 0.35, P <0.001).
早产仍然是产科领域的一个突出问题，对母亲和后代都有重大的不良影响。育龄女性中二尖瓣脱垂（MVP）的发生率引发了人们对怀孕及其相关问题的担忧。本系统评价和荟萃分析的目的是帮助理解有多次分娩史的女性中MVP与早产之间关联的合理性。按照系统评价和荟萃分析的首选报告项目（PRISMA）指南，我们在包括PubMed、Embase、Cochrane图书馆、科学网和Scopus在内的数据库中检索了1999年至2024年期间发表的研究。纳入标准包括队列研究、横断面研究和病例对照研究等，这些研究涉及从总共1029篇文章中筛选出的被诊断为MVP的女性。总体而言，本评价共纳入19项研究，其中3项被考虑进行进一步的荟萃分析。分析显示，当MVP的严重程度为II型和III型时，MVP与早产之间存在关联。证据还强调了对患有二尖瓣脱垂的女性进行随访和采取预防措施对于改善母婴结局的重要性。总体效应大小检验的平均Z值（4.47）和p值（0.00）表明MVP与早产之间存在高度相关性，表明该关联的统计数据令人满意。研究结果确实表明MVP是早产的一个风险因素（合并效应量ES = 0.24，95%可信区间 = 0.14至0.35，P <0.001）。
