Rastogi Simran, Rani Komal, Kumar Saroj
Department of Biophysics, All India Institute of Medical Sciences, New Delhi, India.
Department of Health Science, Luleå University of Technology, Luleå, Sweden.
Neurosci Insights. 2021 Nov 25;16:26331055211058687. doi: 10.1177/26331055211058687. eCollection 2021.
The elusiveness encircling around the domain of cognition, its impairment, and the poor prognosis of Alzheimer's disease has made early diagnosis a necessity. The noticeable symptoms in these conditions appear years later after the neuropathological changes occur in the brain. Exosomes, a small-sized extracellular vesicle facilitate intercellular communication of disease pathologies and their cargo can provide molecular information about its place of origin. The study titled "A novel approach to correlate the salivary exosomes and their protein cargo in the progression of cognitive impairment into Alzheimer's disease" was an attempt toward understanding the role of salivary small-sized extracellular vesicular (EV's) cargo in monitoring the progression. Outcomes of the study represent, that the salivary small-sized EV's (ssEV's) levels were higher in the cognitively impaired and Alzheimer's diseased as well the differential expression of the protein in the cargo correlates well with the disease severity staging. Thus, it can help in the development of an early non-invasive screening method.
围绕认知领域、其损伤以及阿尔茨海默病的不良预后的难以捉摸性使得早期诊断成为必要。这些病症中明显的症状在大脑发生神经病理变化数年之后才会出现。外泌体是一种小型细胞外囊泡，有助于疾病病理的细胞间通讯，其内容物可以提供有关其起源部位的分子信息。题为“一种将唾液外泌体及其蛋白质内容物与认知障碍进展为阿尔茨海默病相关联的新方法”的研究旨在了解唾液小型细胞外囊泡（EV）内容物在监测进展中的作用。该研究结果表明，认知障碍和阿尔茨海默病患者的唾液小型EV（ssEV）水平较高，并且内容物中蛋白质的差异表达与疾病严重程度分期密切相关。因此，它有助于开发一种早期非侵入性筛查方法。
