Research Unit of Diagnosis and Treatment of Chronic Nasal Diseases, Chinese Academy of Medical Sciences, Beijing, China.
Beijing Key Laboratory of Nasal Diseases, Beijing Institute of Otolaryngology, Beijing, China.
Laryngoscope. 2022 Nov;132(11):2103-2110. doi: 10.1002/lary.29974. Epub 2021 Dec 6.
OBJECTIVES/HYPOTHESIS: Air pollution has emerged as an important environmental risk factor for chronic rhinosinusitis (CRS) progression. This study assessed exposure to five types of air pollution (PM , SO , NO , CO, O ) and explored their effects on CRS with nasal polyps (CRSwNP) severity and endotype.
Retrospective cohort study.
Air pollution data from monitoring sites in Beijing were obtained to assess individual air pollution exposure. Outcomes of CRSwNP (n = 282) including Lund-Mackay (L-M) score, Lund-Kennedy (L-K) score, visual analogue scale (VAS) score and nasal patency/airflow resistance and so on were measured to analyze correlations with air pollution and compare groups with different exposure types. Multivariable-adjusted binary logistic regression was used to determine potential air pollution risk factors of the endotype of eosinophilic CRSwNP (ECRSwNP).
Short-term exposures to PM , SO , CO, NO , and O were weak but significantly associated with increased L-M scores. Short-term exposures to PM , CO, and NO were correlated with increased VAS headache/facial pain scores. The L-M scores of the group of the highest PM (≥150 μg/m ) exposure were significantly higher than those of control group. For each increased unit of the average concentration of PM , there was a 1.047-fold (95% confidence interval, 1.005-1.091) increased risk of the endotype of ECRSwNP.
Air pollution exposure exacerbated CRSwNP severity and PM could be a risk factor for endotype of ECRSwNP, suggesting the role of air pollution in CRSwNP pathogenesis.
4 Laryngoscope, 132:2103-2110, 2022.
目的/假设：空气污染已成为慢性鼻-鼻窦炎（CRS）进展的一个重要环境风险因素。本研究评估了五种类型的空气污染（PM 、SO 、NO 、CO 和 O ）的暴露情况，并探讨了它们对伴有鼻息肉（CRSwNP）的 CRS 的严重程度和表型的影响。
回顾性队列研究。
从北京监测点获取空气污染数据，以评估个体的空气污染暴露情况。测量了 282 例 CRSwNP 患者的结局，包括 Lund-Mackay（L-M）评分、Lund-Kennedy（L-K）评分、视觉模拟量表（VAS）评分和鼻通气/气流阻力等，以分析与空气污染的相关性，并比较不同暴露类型的组间差异。采用多变量调整的二项逻辑回归来确定嗜酸粒细胞性 CRSwNP（ECRSwNP）表型的潜在空气污染危险因素。
短期暴露于 PM 、SO 、CO、NO 和 O 与 L-M 评分升高呈弱但显著相关。短期暴露于 PM 、CO 和 NO 与 VAS 头痛/面部疼痛评分升高相关。PM 暴露最高（≥150 μg/m ）组的 L-M 评分明显高于对照组。PM 平均浓度每增加一个单位，ECRSwNP 表型的风险增加 1.047 倍（95%置信区间，1.005-1.091）。
空气污染暴露加重了 CRSwNP 的严重程度，PM 可能是 ECRSwNP 表型的一个危险因素，提示空气污染在 CRSwNP 发病机制中的作用。
4 级喉镜，132：2103-2110，2022。
