Eickhorn R, Haverkampf K, Antoni H
Muscle Nerve. 1986 May;9(4):313-8. doi: 10.1002/mus.880090405.
Frog sciatic nerves were isolated and the middle portion of each exposed to condenser discharges (field strength up to 1000 V/cm; time constants 0.2-8.0 ms) through the bathing fluid. The ability of the nerve to propagate action potentials (AP) was examined by stimulating the proximal end and recording the AP from the distal end of the exposed section. The fraction of the nerve fibers remaining propagative was estimated from the amplitude (or the area) of the compound AP. Strong discharges brought about a total block of propagation lasting for up to 30 minutes, followed by slow, but almost complete, restitution. The restitution was exponential against time and depended on the field strength and duration of the discharge. Discharges equal in energy but different in their voltage--condenser combinations had markedly different actions, with stronger effects being found at higher voltages and vice versa. Hence, the described effects are unlikely to be caused by dissipation of thermal energy only. Other mechanisms (ionic imbalance, dielectric breakdown, punch through) are discussed.
分离出青蛙的坐骨神经，使每根神经的中间部分通过浴液暴露于电容放电（场强高达1000V/cm；时间常数0.2 - 8.0ms）。通过刺激暴露部分的近端并记录远端的动作电位（AP）来检测神经传导动作电位的能力。根据复合动作电位的幅度（或面积）估算仍具有传导能力的神经纤维比例。强放电会导致长达30分钟的完全传导阻滞，随后是缓慢但几乎完全的恢复。恢复呈时间指数关系，并且取决于放电的场强和持续时间。能量相同但电压 - 电容组合不同的放电具有明显不同的作用，在较高电压下效果更强，反之亦然。因此，所描述的效应不太可能仅由热能耗散引起。文中还讨论了其他机制（离子失衡、介质击穿、穿通）。
