Key Laboratory of Molecular Target & Clinical Pharmacology and the State & NMPA Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences & the Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, 511436, P.R. China.
Org Biomol Chem. 2021 Dec 22;20(1):117-121. doi: 10.1039/d1ob02108g.
Selenium-substituted heteroarenes are biologically active compounds and useful building blocks. In this study, we have developed a metal- and oxidant-free, environmentally friendly protocol for the regioselective selenylation of 2-indazole derivatives by an electrochemical strategy. A number of selenylated 2-indazoles with a wide range of functional groups have been synthesized in moderate to good yields under mild and environment-friendly reaction conditions.
硒取代杂芳烃是具有生物活性的化合物，也是有用的构建模块。在这项研究中，我们开发了一种无金属和氧化剂、环保的电化学策略，用于 2-吲哚衍生物的区域选择性硒化反应。在温和、环保的反应条件下，通过电化学策略，以中等至良好的收率合成了一系列具有广泛官能团的硒代 2-吲哚。
