Department of Oral and Maxillofacial Pathology and Microbiology, Post Graduate Institute of Dental Sciences, Pt B.D. Sharma University of Health Sciences, Rohtak, India.
Department of Oral and Maxillofacial Pathology, Saveetha Dental College and Hospitals, Saveetha University (Tamil Nadu), Chennai, India.
Int J Dermatol. 2023 Jan;62(1):22-31. doi: 10.1111/ijd.15974. Epub 2021 Dec 6.
Lichen planus (LP) is a chronic T-cell-mediated mucocutaneous inflammatory disease, largely recognized in adults. It is uncommon in children, and the literature present still lacks comprehensive understanding mainly due to underreporting of such cases. LP shows atypical clinical features, when seen in children, mainly affecting the flexor aspect of the wrists, legs, and the oral and genital mucosae. It is largely considered an autoimmune response of the body with various etiologic factors. Its association with vaccination is still an interesting field for research. The focus of the present systematic review was to discover the link of vaccine in the pathogenesis of juvenile LP. An electronic search was carried out using MEDLINE by PubMed, Google Scholar, and Web of Science databases. Articles that reported LP in children with prior records for vaccination were selected for the present systematic review. Twenty-three published articles in the English language were included for the quantitative and qualitative syntheses. The demographic data, specific vaccine history, and clinical details of the lesions were recorded. The existing evidence supports that vaccines could play an important role in etiopathogenesis of pediatric LP.
扁平苔藓（LP）是一种慢性 T 细胞介导的黏膜炎症性疾病，主要发生在成年人中。它在儿童中罕见，由于此类病例报告较少，目前的文献仍然缺乏全面的认识。LP 在儿童中表现出非典型的临床特征，主要影响手腕、腿部的屈侧以及口腔和生殖器黏膜。它主要被认为是一种机体的自身免疫反应，有多种病因。其与疫苗接种的关联仍然是一个有趣的研究领域。本系统评价的重点是发现疫苗在青少年 LP 发病机制中的作用。使用 MEDLINE 通过 PubMed、Google Scholar 和 Web of Science 数据库进行了电子搜索。选择了有疫苗接种史的儿童 LP 报道的文章进行本系统评价。纳入了 23 篇以英文发表的定量和定性综合分析文章。记录了人口统计学数据、特定疫苗史和病变的临床细节。现有证据支持疫苗可能在儿童 LP 的发病机制中发挥重要作用。
