Yang De-Yong, Liu Liang, Gu Jia-Yi, He Yan-Hong, Guan Zhi
Key Laboratory of Applied Chemistry of Chongqing Municipality, School of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, China.
J Org Chem. 2021 Dec 17;86(24):18042-18055. doi: 10.1021/acs.joc.1c02335. Epub 2021 Dec 6.
A visible-light-initiated radical cascade reaction toward the synthesis of structurally diverse fused Indolo-pyridones is described. The reaction involves the addition of aroyl or sulfonyl radicals to -alkyl-acryloyl-1-indole-3-carboxamides, cyclization, and oxidative aromatization. This telescoped method circumvents lengthy prefunctionalization steps of radical precursors, which is further underpinned by the superior compatibility with a series of C-centered radicals, allowing the rapid and facile construction of numerous valuable architectures.
